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Complications and Pitfalls in Rat Stroke Models for Middle Cerebral Artery Occlusionby Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Müller, Carina Rottger, Alexander Kluge, Manfred Kaps, Marc Fisher, and Georg Bachmann Stroke Volume 35(10): October 1, 2004 Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. Time course of body temperature.Figure 1. Time course of body temperature. Body temperature increased in the permanent suture MCAO group only (group II). In groups I and III, temperature remained within the normal range. Tibo Gerriets et al. Stroke. 2004;35: Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. MCAO techniques.Figure 2. MCAO techniques. Top, Suture technique. After permanent MCAO, MRA (left) indicates occlusion of the ICA and MCA. The suture furthermore occludes the HA and the AChA that originate from the ICA (middle). Brain infarction in the territory of the MCA, AChA and HTA is clearly visible on T2-weighted imaging after 24 hours (right). Bottom, Macrosphere technique. After permanent MCAO, MRA (left) indicates occlusion of the MCA, but not of the proximal part of the intracranial portion of the ICA. The spheres block blood flow to the MCA and to the AChA, but not to the HA. This leads to brain infarction in the MCA and AChA territory, but not in the hypothalamic region (MRI, right). ACA indicates anterior cerebral artery; BA, basilar artery; AChA, anterior chorid artery. Tibo Gerriets et al. Stroke. 2004;35: Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. Model failure (permanent suture MCAO).Figure 3. Model failure (permanent suture MCAO). Inappropriate insertion depths of the suture caused an occlusion of the AChA and the HA, but not of the MCA (left/middle). T2-weighted MRI revealed a small subcortical lesion, suggestive of AChA and HTA territory infarction (right). The animal showed moderate to severe neurological deficits and increased body temperature after 3 hours and 24 hours. Tibo Gerriets et al. Stroke. 2004;35: Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Model failure (subarachnoid hemorrhage).Figure 4. Model failure (subarachnoid hemorrhage). T2-weighted MRI 24h after permanent suture MCAO. Vessel perforation, caused by inappropriate suture insertion depths, resulted in SAH and intracerebral hemorrhage (arrow). Tibo Gerriets et al. Stroke. 2004;35: Copyright © American Heart Association, Inc. All rights reserved.
Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms
Neuroimaging of Stroke Andrew Perron, MD Assistant Professor Department of Emergency Medicine University of Virginia Charlottesville, VA
Vascular Diseases Re-written by: Daniel Habashi Seminar by: Dr. Jezewski.
This lecture was conducted during the Nephrology Unit Grand Ground by a Sub-intern under Nephrology Division, Department of Medicine in King Saud University.
Neuroradiology 1.MRI (diffusion) early ischemic stroke 2.CT for trauma and CVA/stroke to exclude hemorrhage 3.MRA or DSA for Aneurysm (SAH)
MRI of experimental focal cerebral ischaemia in sheep Annette Förschler 1), Johannes Bolze 2), Daniela Waldmin 3), Uwe Gille 3), Claus Zimmer 1) 1) Department.
Progressive fetal intracranial lesion Teaching NeuroImages Neurology Resident and Fellow Section © 2015 American Academy of Neurology.
Dr. Meg-angela Christi M. Amores
Date of download: 6/25/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Stroke or Transient Ischemic Attacks With Basilar.
Date of download: 7/8/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Comparison of MRI and CT for Detection of Acute Intracerebral.
Copyright © 2016 American Medical Association. All rights reserved.
Copyright © 2003 American Medical Association. All rights reserved.
Karin Reuter-Rice, PhD, CPNP-AC, FCCM, FAAN
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Figure 6 Case 6: (A) MRA showed occlusion of the left internal carotid artery. (B) MRI 4 days before cell injection and (C) 7 days after cell injection.
Copyright © 2001 American Medical Association. All rights reserved.
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