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CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA First Author: Vanga Carmen Adina Author: Hutu Simona Botoman Maria Muresan.

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Presentation on theme: "CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA First Author: Vanga Carmen Adina Author: Hutu Simona Botoman Maria Muresan."— Presentation transcript:

1 CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA First Author: Vanga Carmen Adina Author: Hutu Simona Botoman Maria Muresan Ioana Alexandra Simon Ionela Anca Coordinator: Dr. Demian Smaranda

2 Backround Of all the malignant tumors of the spleen, the most common morphological entity is malignant lymphoma, most often with regard to a Non Hodgkin`s Lymphoma (NHL) Tumor invasion of the spleen is usually seen in the evolution of nodal or extranodal NHL onset Primary splenic lymphoma is approximately 1- 2% of NHL

3 Patients and method retrospective cohort study - patients diagnosed, treated and followed in the Ist Medical Clinic - Hematology, during the study was referring mainly on Marginal Zone Lymphoma of the Spleen (MZLS) evaluation of the incidence of various potential prognostic and predictive factors (clinical, biological, morphological factors)

4 R ESULTS P RIMARY SPLENIC NHL, THE DISTRIBUTION OF HISTOLOGICAL SUBTYPES

5 Primary splenic NHL, the distribution by gender

6 P RIMARY SPLENIC NHL, THE DISTRIBUTION BY AGE

7 Clinical and biological parameters with prognostic potential in splenic NHL ParameterMZLS n(%) (N=12)Other histological types n(%) (N=12) Fisher t test (p) Hgb /= 12g/dl 10 (83,33)2 (16,66)<0,05 Tr /= /mm3 4 (33,33)1 (8,33)0,32 LDH >N vs 50mm/h vs { "@context": "http://schema.org", "@type": "ImageObject", "contentUrl": "http://images.slideplayer.com/1402461/3/slides/slide_6.jpg", "name": "Clinical and biological parameters with prognostic potential in splenic NHL ParameterMZLS n(%) (N=12)Other histological types n(%) (N=12) Fisher t test (p) Hgb /= 12g/dl 10 (83,33)2 (16,66)<0,05 Tr /=150.000/mm3 4 (33,33)1 (8,33)0,32 LDH >N vs 50mm/h vs N vs 50mm/h vs

8 Clinical and biological parameters with prognostic potential in splenic NHL ParameterMZLS n(%) (N=12)Other histological types n(%) (N=12) Fisher t test (p) Fibrinogen >N vs /= 2 vs 0-14 (33,33) 1,00 Age >/= 60 years vs <60 years 4 (33,33)6(50,00)0,68 Atc HCV + vs -2 (16,66) 1,00 Atg Hbs + vs -1 (8,33)01,00

9 LSZM PROGNOSIS STRATIFICATION BY PROGNOSTIC INDEX PROPOSED BY INTEGRUPPO ITALIANO LIMFOMI – IIL

10 C ONCLUSIONS Primary splenic NHL is 5.55% of total NHL most common histological subtype was represented by marginal zone lymphoma of the spleen (MZLS) compared with other types of NHL spleen, MZLS was diagnosed more frequently at a young age and female patients

11 C ONCLUSIONS to assess the incidence of clinical prognostic factors in MZLS subgroup were found to differ significantly from the other spleen histology NHL.

12 C ONCLUSIONS careful morphological evaluation, along with immunohistochemical and flow cytometric study appears as an item of great value in the positive and differential diagnosis

13 Thank you for your attention !


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