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The DDAH/ADMA/NOS pathway

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Presentation on theme: "The DDAH/ADMA/NOS pathway"— Presentation transcript:

1 The DDAH/ADMA/NOS pathway
Cam T.L Tran, James M Leiper, Patrick Vallance  Atherosclerosis Supplements  Volume 4, Issue 4, Pages (December 2003) DOI: /S (03)

2 Fig. 1 Structure of l-arginine and endogenous methylarginines l-NMMA, ADMA and SDMA. Only l-NMMA and ADMA are nitric oxide synthase inhibitors. Atherosclerosis Supplements 2003 4, 33-40DOI: ( /S (03) )

3 Fig. 2 Proposed mechanism for regulation of nitric oxide production by DDAH, suggested initially by [28]. Atherosclerosis Supplements 2003 4, 33-40DOI: ( /S (03) )

4 Fig. 3 Chromosomal localization of human DDAH1 and DDAH2 genes.
Atherosclerosis Supplements 2003 4, 33-40DOI: ( /S (03) )


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