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A Systematic Review and Meta-analysis of the Literature: Chemotherapy and Surgery versus Surgery Alone in Non-small Cell Lung Cancer  Sarah Burdett, MSc,

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Presentation on theme: "A Systematic Review and Meta-analysis of the Literature: Chemotherapy and Surgery versus Surgery Alone in Non-small Cell Lung Cancer  Sarah Burdett, MSc,"— Presentation transcript:

1 A Systematic Review and Meta-analysis of the Literature: Chemotherapy and Surgery versus Surgery Alone in Non-small Cell Lung Cancer  Sarah Burdett, MSc, Lesley A. Stewart, PhD, Larysa Rydzewska, BSc  Journal of Thoracic Oncology  Volume 1, Issue 7, Pages (September 2006) DOI: /S (15) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Results of searches for RCTs.
Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Hazard ratio plot for overall survival. Each individual trial is represented by a square, the center of which denotes the hazard ratio for that trial. The extremities of the horizontal bars denote the 99% CIs and the inner bars mark the 95% CIs. The size of the square is directly proportional to the amount of information in the trial. The filled diamond at the bottom of the plot gives an overall hazard ratio for the combined results of all trials. The center of the diamond denotes the hazard ratio for all trials and the extremities the 95% CIs. Trials are ordered chronologically by the age of the trial, with the oldest listed first. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Hazard ratio plot for sensitivity analysis for overall survival. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Hazard ratio plot for overall survival by chemotherapy grouping. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 Hazard ratio plot for overall survival by postoperative treatment. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

7 FIGURE 6 Hazard ratio plot for disease-free survival.
Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

8 FIGURE 7 Begg's and Egger's tests for publication bias.
Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

9 FIGURE 8 Begg's graph for publication bias.
Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

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