Presentation on theme: "SUN−336 HIGH PREVALENCE OF VITAMIN D DEFFICIENCY AND ITS ASSOCIATION WITH METABOLIC SYNDROME IN ELDERLY MEN LIVING IN THE TROPICS INTRODUCTION An inverse."— Presentation transcript:
SUN−336 HIGH PREVALENCE OF VITAMIN D DEFFICIENCY AND ITS ASSOCIATION WITH METABOLIC SYNDROME IN ELDERLY MEN LIVING IN THE TROPICS INTRODUCTION An inverse association between serum 25OHD levels and metabolic syndrome (MS) has been proposed, but the data so far are controversial especially related to the cut point used. Mean serum 25OHD was 27.87±13.52 ng/ml, BMI 25.67 ±4.31 Kg/m 2 and sun index (hours of sun exposure per week x fraction of body surface area exposed) 5.49 ±5.05. The prevalence of vitamin D deficiency was 31.5% (95% CI 26.2-36.8) and 66.7% (95% CI 61.3-72.1) when cutoff of less than 20ng/ml and 30ng/ml were used, respectively. 70,5% had hypertension; 64,2% high fasting plasma glucose (≥ 100mg/dL); 42,3% had high triglycerides (≥150 mg/dL); 47,4% low HDL-c ( 94cm) and 32,4% according to NCEP (> 102cm). When evaluating the number of criteria for MS (NCEP) we found that: 4,4% didn't have any; 17,6% had one; 23,4% had two; 30,8% had three; 19,8% had four and 4,0% had five. Among patients with no MS criteria, 50% had 25OHD<30ng/mL and 24% < 20ng/mL. In contrast, for those with 5 MS criteria, 72,7% had 25OHD <30ng/mL and 36,4% < 20ng/mL. CONCLUSION Our data suggest that regular sun exposure in the elderly without protection in daily life doesn’t protect against 25OHD levels less than 30ng/ml and that vitamin D deficiency was independently associated with metabolic risk. REFERENCES METHODS We evaluated the serum levels of 25OHD, sun index and metabolic risk factors in 284 men (age +-SD 69.44 yr ±6.49) attending primary care clinics. Marcelo Cabral, Juliana Maia, Manoel Soares Filho, Leonardo Bandeira, Francisco Bandeira Division of Endocrinology, Diabetes and Bone Disease, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil www.ued-ham.org.br Figure 1 – Cardiovascular risk factors, vitamin D deficiency and calcium intake of study patients Figure 3 - Prevalence of vitamin D deficiency in elderly men according to MS charge SUN-264 RESULTS Figure 2 – Metabolic syndrome charge OBJECTIVE The aim of the present study was to determine the prevalence of vitamin D deficiency among elderly men and its association with metabolic syndrome in the city of Recife, Brazil (8 o S). In a univariate analysis, patients who had 25OHD 20ng/ml (4,46 ±3,69 vs 6,01 ±5.4; p=0.006) and this association was not statistically significant using the cutoff of 30ng/ml (5,22 ±4,43 vs 6,12 ±6,14; p=0.180). Patients with 25OHD 20ng/ml (25,91 ±4,73 vs 24,95 ±4,21; p=0.045) and this was also true for those with 25OHD <30ng/ml (26,12 ±4,92 vs 25,08 ±4,19; p=0.018). After adjustment for possible confounders by multiple regression analyses, sun index was independent and positively associated with serum 25OHD levels (p=0,005); BMI and presence of MS (NCEP) were independent and inversely associated with serum 25OHD levels (p=0,005 and p=0,007, respectively). 1- Bandeira F, Griz L, Dreyer P et al. Vitamin D deficiency: a global perspective. Arq Bras Endocrinol Metabol 2006; 50(4):640-646. 2- Cabral M, Borges C, Fontan D, Bandeira L, Chaves N, Bandeira F. Prevalence of Vitamin D Deficiency and Its Relationship with Sun Exposure and Skin Phototype in Enderly Men Living in the Tropics; J Bone Miner Res 2011; 26 (Suppl 1): S-524 3-Thomas G, Hartaigh J, Bosch J et al. Vitamn D levels predict all- cause and cardiovascular disease mortality In subjects with the metabolic syndrome: The LURIC study. Diabetes Care 2012; 35:1158-1164.