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High-Risk Human Papillomavirus–Positive Lung Cancer: Molecular Evidence for a Pattern of Pulmonary Metastasis  Robert A.A. van Boerdonk, MSc, Johannes.

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Presentation on theme: "High-Risk Human Papillomavirus–Positive Lung Cancer: Molecular Evidence for a Pattern of Pulmonary Metastasis  Robert A.A. van Boerdonk, MSc, Johannes."— Presentation transcript:

1 High-Risk Human Papillomavirus–Positive Lung Cancer: Molecular Evidence for a Pattern of Pulmonary Metastasis  Robert A.A. van Boerdonk, MSc, Johannes M.A. Daniels, MD, PhD, Elisabeth Bloemena, MD, PhD, Oscar Krijgsman, MSc, Renske D.M. Steenbergen, PhD, Ruud H. Brakenhoff, PhD, Katrien Grünberg, MD, PhD, Bauke Ylstra, PhD, Chris J.L.M. Meijer, MD, PhD, Egbert F. Smit, MD, PhD, Peter J.F. Snijders, PhD, Daniëlle A.M. Heideman, PhD  Journal of Thoracic Oncology  Volume 8, Issue 6, Pages (June 2013) DOI: /JTO.0b013e c14 Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 p16INK4A Expression patterns in tumor pairs. Immunohistochemical staining patterns for p16INK4A are shown for (A) paired tumors of case 1, (B) LC of case 2, and (C) paired tumors of case 3. Photograps were taken using a 100× magnification. AdCa, adenocarcinoma; LC, lung cancer; SCC, squamous cell carcinoma. Journal of Thoracic Oncology 2013 8, DOI: ( /JTO.0b013e c14) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Genomic profiles support a common clonal origin in tumor pairs. DNA copy number aberrations for tumor pairs originating from (A) case 1 and (B) case 3 as detected by array CGH are shown. Genomic profiles were aligned according to chromosomal position (x axis) and display log2 tumor to normal ratios (y axis). Both individual array measurements (180K in total, represented by gray dots) and respective segmented values (black lines) are indicated. Gain and loss are positive and negative log2 ratio, respectively. Journal of Thoracic Oncology 2013 8, DOI: ( /JTO.0b013e c14) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

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