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Fig. 4. Relationships of changes in CRP or SAA to changes in body weight and insulin resistance. For each comparison the regression line is shown (solid.

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Presentation on theme: "Fig. 4. Relationships of changes in CRP or SAA to changes in body weight and insulin resistance. For each comparison the regression line is shown (solid."— Presentation transcript:

1 Fig. 4. Relationships of changes in CRP or SAA to changes in body weight and insulin resistance. For each comparison the regression line is shown (solid line) along with its 95% confidence intervals (dotted curves). A, Change in CRP vs. change in weight. For the 41 participants, there was a significant correlation between change in LogCRP and change in body weight (r = 0.34, P = 0.03). B, Change in SAA vs. change in weight. Similarly, for the 41 participants, there was a highly significant correlation between change in LogSAA and change in body weight (r = 0.44, P = 0.004). C, Change in CRP vs. change in insulin resistance. For 40 participants with basal insulin and glucose levels, there was no relationship between change in LogCRP and change in insulin resistance, as calculated by HOMA (r = 0.07, P = 0.66). D, Change in SAA vs. change in insulin resistance. In contrast, there was a significant correlation between change in LogSAA and change in insulin resistance (r = 0.32, P = 0.04). From: Diet-Induced Weight Loss Is Associated with Decreases in Plasma Serum Amyloid A and C-Reactive Protein Independent of Dietary Macronutrient Composition in Obese Subjects J Clin Endocrinol Metab. 2005;90(4): doi: /jc J Clin Endocrinol Metab | Copyright © 2005 by The Endocrine Society

2 Fig. 3. Correlation between changes in CRP and SAA level and lack of correlation between changes in body weight and insulin resistance. For each comparison the regression line is shown (solid line) along with its 95% confidence intervals (dotted curves). A, Change in CRP vs. change in SAA. Changes in LogCRP and LogSAA levels were highly correlated (n = 41). B, Change in body weight and change in insulin resistance. In contrast, body weight change and insulin resistance change were not correlated (n = 40). From: Diet-Induced Weight Loss Is Associated with Decreases in Plasma Serum Amyloid A and C-Reactive Protein Independent of Dietary Macronutrient Composition in Obese Subjects J Clin Endocrinol Metab. 2005;90(4): doi: /jc J Clin Endocrinol Metab | Copyright © 2005 by The Endocrine Society

3 Fig. 2. CRP and SAA changes by diet group. A, CRP change by diet group
Fig. 2. CRP and SAA changes by diet group. A, CRP change by diet group. There was no significant difference in the decreases in LogCRP levels for the low-carbohydrate group, compared with the low-fat group over 3 months (P = 0.20). B, SAA change by diet group. The decrease in LogSAA levels over 3 months was significantly greater for the low-carbohydrate group, compared with the low-fat group (P = 0.04). From: Diet-Induced Weight Loss Is Associated with Decreases in Plasma Serum Amyloid A and C-Reactive Protein Independent of Dietary Macronutrient Composition in Obese Subjects J Clin Endocrinol Metab. 2005;90(4): doi: /jc J Clin Endocrinol Metab | Copyright © 2005 by The Endocrine Society

4 Fig. 1. Dietary intervention is associated with decreases in LogCRP and LogSAA levels. Data are graphed either as scatterplots, in which median values are indicated by a horizontal line (A and C) or as box and whisker plots (B and D), which show median (center line of box), 75th and 25th percentiles (upper and lower bounds of the box), and 90th and 10th percentile values (upper and lower whiskers). A and B, CRP change for all participants. For all 41 participants in the study, the change in CRP levels from baseline to 3 months did not reach significance (A), but LogCRP levels decreased significantly from baseline to 3 months (P = 0.035). C and D, SAA change for all participants. Similarly, the change in SAA levels from baseline to 3 months did not reach significance (C), but LogSAA levels decreased significantly from baseline to 3 months (D, P = 0.049). From: Diet-Induced Weight Loss Is Associated with Decreases in Plasma Serum Amyloid A and C-Reactive Protein Independent of Dietary Macronutrient Composition in Obese Subjects J Clin Endocrinol Metab. 2005;90(4): doi: /jc J Clin Endocrinol Metab | Copyright © 2005 by The Endocrine Society


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