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ISI Foundation G. Matullo, P. Vineis M. Manuguerra, F. Saletta DNA repair genes and cancer Web registry on DNA repair polymorphisms and cancer risk website.

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Presentation on theme: "ISI Foundation G. Matullo, P. Vineis M. Manuguerra, F. Saletta DNA repair genes and cancer Web registry on DNA repair polymorphisms and cancer risk website."— Presentation transcript:

1 ISI Foundation G. Matullo, P. Vineis M. Manuguerra, F. Saletta DNA repair genes and cancer Web registry on DNA repair polymorphisms and cancer risk website

2 The format of the database is organized by polymorphism and by study, and the contents are: - genetic characterization of the polymorphism - functional data on the physiological and pathological consequences of structural changes in genes and the related protein products (to be implemented)

3 - design of the studies in detail : choice of controls type and stage of disease covariates methods for phenotyping/genotyping - results in detail (Odds Ratios with confidence limits; disaggregation by gender, age, exposure...)

4 Future additional features: It will become possible to prepare meta-analyses and funnel plots from the website We are preparing a matrix of phenotype-genotype correlations, based partly on he literature partly on research in our laboratory (SNP vs. COMET, HCRA, DNA adduct, 8-OH (d)G) Example: 3 SNP for XPD, XRCC1, XRCC3 in 634 healthy subjects from EPIC, and DNA adducts

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6 ISI FOUNDATION, TURIN, ITALY

7 ISI FOUNDATION, TURIN, ITALY

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