1. HIV and STI Department, Health Protection Agency - Colindale HIV and AIDS Reporting System HIV in the UK – 30 years on… Since 1981: 122,000 HIV diagnoses 27,500 AIDS diagnoses 20,500 deaths In 2011: 6280 new diagnoses 73,700 in HIV care 96,000 (90,800-102,500) living with HIV 24% (18%-30%) undiagnosed Overall prevalence: 1.5 per 1,000 population

2. HIV and STI Department, Health Protection Agency - Colindale HIV and AIDS Reporting System People living with HIV infection: UK 2011

3. HIV and STI Department, Health Protection Agency - Colindale HIV and AIDS Reporting System New HIV diagnoses by exposure group: UK 2002–2011 1

4. HIV and STI Department, Health Protection Agency - Colindale HIV and AIDS Reporting System HIV Incidence in MSM: Counter factual scenarios (a)ART never introduces (b)No condom use (c)ART at diagnosis from 2000 (d)Increased testing rates (e)Higher testing and ART at diagnosis (a)(b)(c) (d)(e) Phillips A.N., Cambiano V, Nakagawa F et al (2013). Increased HIV Incidence in Men Who Have Sex with Men Despite High Levels of ART-Induced Viral Suppression: Analysis of an Extensively Documented Epidemic. PLoS ONE 8(2): e55312. doi:10.1371/journal.pone.0055312

5. HIV and STI Department, Health Protection Agency - Colindale HIV and AIDS Reporting System Aging Average age at diagnosis is 35 In 2008 1/6 over 50 – > 50s fastest growing group Life expectancy predicted now near normal with Rx HIV associated with other comorbidities esp metabolic/cardiovascular Move to Chronic Disease Management

6. HIV and STI Department, Health Protection Agency - Colindale HIV and AIDS Reporting System Health Inequality MSM and Black Africans over-represented Different approach needed to address their needs Poorest areas have the highest prevalence Need to tackle socioeconomic issues and stigma Prevalence of diagnosed HIV infection by region of residence among population aged 15-59 years: United Kingdom, 2011 London >2 1-2 <1