1. Fig. 8. Changes of caspase-3 (A), Bcl-2 (B), IL-6 (C), TNF-α (D), VEGF (E) and BNP (F) protein expression levels after hUCB-MSCs injection in PAH rat heart tissues. The protein expressions of caspase-3, Bcl-2 and TNF-α were greatly decreased in the U group, as compared with the M group at week 2. The protein expressions of VEGF, IL-6 and BNP were significantly decreased in the U group in comparison with the M group at weeks 2 and 4 (p<0.05). *p<0.05 compared with the C group, †p<0.05 compared with the M group. C: control group, M: monocrotaline group, U: human umbilical mesenchymal stem cells group, Bcl: B cell leukemia/lymphoma-2, VEGF: vascular endothelial growth factor, IL: interleukin, TNF: tumor necrosis factor, BNP: brain natriuretic peptide, PAH: pulmonary arterial hypertension, wk: week.
Fig. 8. Changes of caspase-3 (A), Bcl-2 (B), IL-6 (C), TNF-α (D), VEGF (E) and BNP (F) protein expression levels after hUCB-MSCs injection in PAH rat heart tissues. The protein expressions of caspase-3, Bcl-2 and TNF-α were greatly decreased in the U group, as compared with the M group at week 2. The protein expressions of VEGF, IL-6 and BNP were significantly decreased. . .
Korean Circ J Jan;46(1):