1. Persistence of androgenic effects on the production of proinflammatory cytokines by circulating antigen-presenting cells after withdrawal of testosterone treatment in aging type 2 diabetic men with partial androgen deficiency 
Juan José Corrales, M.D., María Almeida, Ph.D., José Manuel Miralles, M.D., Alberto Orfao, M.D. 
Fertility and Sterility 
Volume 92, Issue 1, Pages (July 2009)
DOI: /j.fertnstert
Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Distribution of total leukocytes, monocytes, and polymorphonuclear cells, as well as different subsets of T cells and dendritic cells in PB samples from type 2 diabetic men before treatment, after 12 months of treatment, and 3 months after withdrawal of T replacement therapy in comparison with a group of age-matched healthy male control subjects. Notched boxes represent 25th and 75th percentile values; the line in the middle and vertical lines correspond to the median value and the 10th and 90th percentiles, respectively. Blue boxes and green boxes represent healthy controls and type 2 diabetic men, respectively. N = absolute number; TX = androgen replacement therapy; PMN = polymorphonuclear; NK cells = natural killer cells; CT = controls; BF.TX = before TX; +12M.TX = after 12 months of TX; +3M.TX WD = 3 months after TX withdrawal. ∗P≤.05 vs. controls; ∗∗P≤.01 vs. controls; ++P≤.01 vs. before TX.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
In vitro stimulated secretion of inflammatory cytokines by PB monocytes and DC from type 2 diabetic men with partial androgen deficiency before treatment with T, after 12 months of treatment, and 3 months after withdrawal of T replacement therapy in comparison with a group of age-matched healthy male control subjects. Notched boxes represent 25th and 75th percentile values; the line in the middle and vertical lines correspond to the median value and the 10th and 90th percentiles, respectively. Yellow boxes and red boxes represent the percentage of cytokine-producing cells from healthy controls and type 2 patients, respectively. Blue boxes and green boxes represent the mean amount of cytokines produced (evaluated as the mean fluorescence intensity) by healthy controls and type 2 diabetic patients, respectively. TX = androgen replacement therapy; DC = dendritic cells; MFI = mean fluorescence intensity (arbitrary relative linear units scaled from 0 to 10,000); CT = controls; BF.TX = before TX; +12M.TX = after 12 months of TX; +3M.TX WD = 3 months after TX withdrawal. ∗P≤.05, ∗∗P≤.01 vs. controls; +P≤.05 and ++P≤.01 vs. before TX; aaP≤.01 vs. after withdrawal.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions