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Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia  Jacob J. Christensen,

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Presentation on theme: "Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia  Jacob J. Christensen,"— Presentation transcript:

1 Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia  Jacob J. Christensen, Liv T. Osnes, Bente Halvorsen, Kjetil Retterstøl, Martin P. Bogsrud, Cecilie Wium, Arne Svilaas, Ingunn Narverud, Stine M. Ulven, Pål Aukrust, Kirsten B. Holven  Atherosclerosis  Volume 256, Pages (January 2017) DOI: /j.atherosclerosis Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Representative flow cytometry plots of the three main monocyte subpopulations. (A) FH child with low HDL-C (<1.3 mmol/L), (B) FH child with high HDL-C (≥1.3 mmol/L), and (C) normocholesterolemic child, illustrating the skewing towards pro-inflammatory cells in the former. Monocytes were gated on SSC/FCS and divided into subpopulations; classical monocytes (CD14++ CD16−), pro-inflammatory monocytes (CD14++ CD16+) and non-classical monocytes (CD14 + CD16+). Atherosclerosis  , 67-74DOI: ( /j.atherosclerosis ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Serum concentration of endothelial cell adhesion molecules. (A and B) ICAM-1, (C and D) VCAM-1 and (E and F) E-selectin, as determined by enzyme immunoassays. Lines represent median values within each group. p values are independent samples T test using non-transformed data for ICAM-1 and VCAM-1, and log-transformed data for E-selectin. Atherosclerosis  , 67-74DOI: ( /j.atherosclerosis ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

4 Atherosclerosis 2017 256, 67-74DOI: (10. 1016/j. atherosclerosis. 2016
Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions


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