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The gate theory proposed that small (C) fibers activated excitatory systems (black neuron) that subsequently excited output cells—these latter cells had.

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Presentation on theme: "The gate theory proposed that small (C) fibers activated excitatory systems (black neuron) that subsequently excited output cells—these latter cells had."— Presentation transcript:

1 The gate theory proposed that small (C) fibers activated excitatory systems (black neuron) that subsequently excited output cells—these latter cells had their activity controlled by the balance of large fibers (A-β)-mediated inhibitions (mediated by endogenous opioids) and also by descending control systems from the central nervous system (mediated by norepinephrine and serotonin). (Reprinted, with permission, from: Dickenson AH: Gate control theory of pain stands the test of time. Br J Anaesth 2002;88:755–757.) Source: Section Two. Pharmacology, NYSORA Textbook of Regional Anesthesia and Acute Pain Management Citation: Hadzic A. NYSORA Textbook of Regional Anesthesia and Acute Pain Management; 2007 Available at: Accessed: November 08, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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