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BM SPL PB Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+

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Presentation on theme: "BM SPL PB Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+"— Presentation transcript:

1 BET-EFF (MV-4-11): 6/6/16 (21 Days Rx) Sacrificing 6 Mice – Tumor Burden
BM SPL PB Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+ (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (Vehicle) (Vehicle)

2 (From Apoptosis Assay)
BET-EFF (MV-4-11): 6/6/16 (21 Days Rx) Sacrificing 6 Mice – Tumor Burden (From Apoptosis Assay) BM SPL PB Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) 20mg/kg I-BET) (Vehicle) (Vehicle)

3 (From Apoptosis Assay)
BET-EFF (MV-4-11): 6/1/16 & 6/2/16 (16 & 17 Days Rx) Sacrificing Mice – Tumor Burden (From Apoptosis Assay) BM SPL MV-4-11 Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ (20mg/kg I-BET) (Vehicle) (20mg/kg I=BET) (Vehicle) PB Live Cells Nucleated cells HLA-ABC+

4 BET-EFF (MV-4-11): 6/6/16 (21 Days Rx) Sacrificing 6 Mice – Apoptosis (Annexin V Assay)
BM SPL PB HLA-ABC+ Annexin V vs IP HLA-ABC+ Annexin V vs PI HLA-ABC+ Annexin V vs PI (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (Vehicle) (Vehicle)

5 BET-EFF (MV-4-11): 6/1/16 & 6/2/16 (16 & 17 Days Rx) Sacrificing Mice – Apoptosis (Annexin V Assay) BM SPL MV-4-11 HLA-ABC+ Annexin V vs IP HLA-ABC+ Annexin V vs PI HLA-ABC+ Annexin V vs PI (20mg/kg I-BET) (Vehicle) 20mg/kg I=BET) (Vehicle) PB HLA-ABC+ Annexin V vs PI

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