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β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas
Carlos Gamallo, José Palacios, Gema Moreno, Jorge Calvo de Mora, Asunción Suárez, Alvaro Armas The American Journal of Pathology Volume 155, Issue 2, Pages (August 1999) DOI: /S (10) Copyright © 1999 American Society for Investigative Pathology Terms and Conditions
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Figure 1 A: Nuclear β-catenin expression pattern in an endometrioid carcinoma. B: Membranous β-catenin expression pattern in an endometrioid carcinoma. C: Nuclear β-catenin expression in some nuclei of epithelial cells of an endometriotic cyst. D. Normal sequence of codons 32 and 33 in exon 3 of β-catenin gene. E: GAC to GGC change in codon 32 (D32G) in tumor 1. F: GAC to TAC change in codon 32 (D32Y) in tumor 3. G: TCT to TGT change in codon 33 (S33C) in tumor 4. H: Analysis with HinfI restriction endonuclease of PCR products from cases 3 and 4. In normal tissue (N) digestion produces three fragments of 133, 60, and 7 bp. In tumor tissues, heterozygous mutations in codons 32 and 33 eliminate a restriction site in the mutated allele and generate an additional fragment of 67 bp. The American Journal of Pathology , DOI: ( /S (10) ) Copyright © 1999 American Society for Investigative Pathology Terms and Conditions
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Figure 2 Reported point mutation in exon 3 of β-catenin gene in human carcinoma samples (excluding preinvasive lesions and cell lines). Bold letters indicate phosphorylated amino acids by GSK-3β. Underlined letters indicate mutated amino acids (D Asp; S Ser; G Gly; T Thr) (refs. 17, 21, 23-27, and this series). The American Journal of Pathology , DOI: ( /S (10) ) Copyright © 1999 American Society for Investigative Pathology Terms and Conditions
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