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Fibromyalgia – physiological aspects Eva Kosek, MD., PhD., Assistant Professor Department of Clinical Neuroscience, Karolinska Institute and Stockholm.

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Presentation on theme: "Fibromyalgia – physiological aspects Eva Kosek, MD., PhD., Assistant Professor Department of Clinical Neuroscience, Karolinska Institute and Stockholm."— Presentation transcript:

1 Fibromyalgia – physiological aspects Eva Kosek, MD., PhD., Assistant Professor Department of Clinical Neuroscience, Karolinska Institute and Stockholm Spine Center, Stockholm, Sweden. Lausanne

2 Fibromyalgia - ACR 1990 criteria. History of widespread pain > 3 months Pain in at least 11 of 18 tender points on digital palpation. Wolfe et al., 1990

3 CWP + TP = FMS (0.5-4%) Female/male ratio 10:1 CWP (10-11%) Female/male ratio 1½:1 TP count - a crude screening tool for disturbed sensory processing? Clauw and Crofford 2003

4 Increased pain sensitivity to all tested modalities Pressure pain Heat pain Kosek et al 1995, 1996

5 Subjectively similar pain intensity: Similar central nervous system activation in both groups. Same intensity of pressure stimulation: More pronounced and bilateral CNS activation in FM patients compared to healthy controls. Evidence of enhanced transmission/ processing of painful stimuli Gracely et al., 2002

6 Left amygdala Nucleus accumbens Right dorsal ACC Lower my-opioidreceptor bindning capacity in patients with fibromyalgia Harris et al Abnormal concentrations of pain related transmittor substances in the cerebrospinal fluid (i.e., serotonin, SP, glutamate) Russell et al. 1992, 2002 Sarchielli et al. 2007

7 FMS patients have increased sensitivity to somatosensory stimuli independently of emotional factors – indicating augmentation of pain transmission and/or processing.

8 Future Challenges Develop clinically useful diagnostic tools to detect facilitation, central sensitisation/disinhibition in individual patients Further development of new treatments targeting these CNS-abnormalities Investigate the possibilities of secondary prevention


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