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Meta-Analysis of Three Randomized Trials and Nine Observational Studies Comparing Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected.

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Presentation on theme: "Meta-Analysis of Three Randomized Trials and Nine Observational Studies Comparing Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected."— Presentation transcript:

1 Meta-Analysis of Three Randomized Trials and Nine Observational Studies Comparing Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Disease  Jae-Sik Jang, MD, PhD, Kyu-Nam Choi, MD, Han-Young Jin, MD, Jeong-Sook Seo, MD, PhD, Tae-Hyun Yang, MD, PhD, Dae-Kyeong Kim, MD, PhD, Dong-Soo Kim, MD, PhD, Sang-Hwa Urm, MD, PhD, Jin Ho Chun, MD, PhD, Soo-Jin Kang, MD, PhD, Duk-Woo Park, MD, PhD, Seung-Whan Lee, MD, PhD, Young-Hak Kim, MD, PhD, Cheol Whan Lee, MD, PhD, Seong-Wook Park, MD, PhD, Seung- Jung Park, MD, PhD  American Journal of Cardiology  Volume 110, Issue 10, Pages (November 2012) DOI: /j.amjcard Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Flow diagram demonstrating inclusion/exclusion process for studies incorporated in final analyses. BMS = bare-metal stent. American Journal of Cardiology  , DOI: ( /j.amjcard ) Copyright © 2012 Elsevier Inc. Terms and Conditions

3 Figure 2 Forest plot of odds ratio for mortality after treatment for unprotected left main coronary artery disease in patients treated with drug-eluting stents versus coronary artery bypass grafting stratified according to study design. CUSTOMIZE = Customized Strategy for Left Main Revascularization; M-H = Mantel–Haenszel; MAIN-COMPARE = Revitalization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization. American Journal of Cardiology  , DOI: ( /j.amjcard ) Copyright © 2012 Elsevier Inc. Terms and Conditions

4 Figure 3 Forest plot of odds ratio for composite end points in patients treated with drug-eluting stents versus coronary artery bypass grafting. Composite end points were mortality, myocardial infarction, or stroke. Abbreviations as in Figure 2. American Journal of Cardiology  , DOI: ( /j.amjcard ) Copyright © 2012 Elsevier Inc. Terms and Conditions

5 Figure 4 Forest plot of odds ratio for target vessel revascularization in patients treated with drug-eluting stents versus coronary artery bypass grafting. Abbreviations as in Figure 2. American Journal of Cardiology  , DOI: ( /j.amjcard ) Copyright © 2012 Elsevier Inc. Terms and Conditions

6 Figure 5 Funnel plot of composite end point of death, myocardial infarction, or stroke indicates the existence of publication bias with an asymmetrical funnel plot in the direction favoring coronary artery bypass grafting. Also depicted are hypothetical missing studies by the trim-and-fill method (open circles). American Journal of Cardiology  , DOI: ( /j.amjcard ) Copyright © 2012 Elsevier Inc. Terms and Conditions


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