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Effects of Medroxyprogesterone Acetate in Obstructive Sleep Apnea

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Presentation on theme: "Effects of Medroxyprogesterone Acetate in Obstructive Sleep Apnea"— Presentation transcript:

1 Effects of Medroxyprogesterone Acetate in Obstructive Sleep Apnea
Krishnan R. Rajagopal, M.D., F.C.C.P., Peter H. Abbrecht, M.D., Ph.D., F.C.C.P., Bahman Jabbari, M.D.  CHEST  Volume 90, Issue 6, Pages (December 1986) DOI: /chest Copyright © 1986 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Percentage of total sleep time spent in episodes of apnea and disordered breathing before, during, and after treatment with medroxyprogesterone acetate (MPA). Values shown are means for all patients (±SE). There were no significant differences associated with treatment. CHEST  , DOI: ( /chest ) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Mean duration of episodes of apnea and disordered breathing for all patients. Brackets indicate ± SE. There were no significant differences associated with treatment with medroxyprogesterone acetate (MPA). CHEST  , DOI: ( /chest ) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Mean numbers of episodes of apnea of various durations for all patients before, during, and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. There were no significant differences associated with treatment. CHEST  , DOI: ( /chest ) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Mean reduction in SaO2 occurring in episodes of apnea and disordered breathing for all patients before, during, and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. There were no significant differences associated with treatment. CHEST  , DOI: ( /chest ) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Mean slopes of linear regressions of minute ventilation ( V ˙ E ) and occlusion pressure (P100) responses on expired Pco2 for all patients before, during and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. Asterisk indicates mean value obtained during treatment significantly greater (p<0.05) than before treatment. CHEST  , DOI: ( /chest ) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

7 Figure 6 Mean percentage of sleep time spent in different sleep stages for all patients before, during, and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. Asterisk indicates value after treatment significantly different (p<0.05) from during treatment and before treatment. CHEST  , DOI: ( /chest ) Copyright © 1986 The American College of Chest Physicians Terms and Conditions


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