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The Registry of the International Society for Heart and Lung Transplantation: Twenty- seventh official adult heart transplant report—2010  Josef Stehlik,

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Presentation on theme: "The Registry of the International Society for Heart and Lung Transplantation: Twenty- seventh official adult heart transplant report—2010  Josef Stehlik,"— Presentation transcript:

1 The Registry of the International Society for Heart and Lung Transplantation: Twenty- seventh official adult heart transplant report—2010  Josef Stehlik, MD, MPH, Leah B. Edwards, PhD, Anna Y. Kucheryavaya, MS, Paul Aurora, PhD, MRCP, Jason D. Christie, MD, MS, Richard Kirk, MA, FRCP, FRCPCH, Fabienne Dobbels, PhD, Axel O. Rahmel, MD, Marshall I. Hertz, MD  The Journal of Heart and Lung Transplantation  Volume 29, Issue 10, Pages (October 2010) DOI: /j.healun Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

2 Figure 1 Number of heart transplant procedures reported to the International Society for Heart and Lung Transplantation (ISHLT) Registry by year and stratified by geographic location. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

3 Figure 2 Etiology of heart disease resulting in adult heart transplantation stratified by geographic location. CAD, ischemic cardiomyopathy; myopathy, non-ischemic cardiomyopathy. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

4 Figure 3 Adult patients bridged to heart transplantation with mechanical circulatory support, including left ventricular assist device (LVAD), right ventricular assist device (RVAD), or biventricular support (LVAD plus RVAD, total artificial heart). The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

5 Figure 4 Changes in the age distribution of heart donors over time. Colored areas represent proportion of donors in the appropriate age group; corresponding y-axis is on the left. The red line represents mean donor age; corresponding y-axis is on the right. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

6 Figure 5 Age distribution of donor hearts in different geographic locations for adult heart transplants performed between January 2000 and June 2009. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

7 Figure 6 Allograft ischemic time distribution in different geographic locations for adult heart transplants performed between January 2000 and June 2009. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

8 Figure 7 Immunosuppressive induction therapy for adult heart transplants performed between January 2002 and June ALG, anti-lymphocyte globulin; ATG, anti-thymocyte globulin; IL-2R, interleukin-2 receptor. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

9 Figure 8 Maintenance immunosuppressive agents at the 1- and 5-year post-transplant follow-up. This includes adult heart recipients with follow-up between January 2007 and June MMF, mycophenolate mofetil; MPA, mycophenolic acid. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

10 Figure 9 Survival for adult and pediatric heart transplants performed between January 1982 and June Conditional median survival is the time to 50% survival for those recipients surviving the first post-transplantation year. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

11 Figure 10 Survival for adult heart transplants performed between January 1982 and June 2008, stratified by era of transplant. NA, not available. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

12 Figure 11 Survival for adult heart transplants performed between January 1982 and June 2008 and surviving to 1 year after transplant, stratified by era of transplant. NA, not available. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

13 Figure 12 Survival at 1 year after adult heart retransplant, stratified by era and time elapsed between original transplant and retransplant. The absolute number of retransplants performed is shown in vertical bars. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

14 Figure 13 Recipient age and relative risk of mortality at 1 year after transplant, for transplants performed January 2003—June The dashed lines show the 95% confidence intervals. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

15 Figure 14 Survival after adult heart transplants performed between January 2002 and June 2008 in patients bridged with left ventricular assist devices (LVAD). The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

16 Figure 15 Survival in patients bridged with ventricular assist devices (LVAD), for adult heart transplants performed between January 1999 and June 2008, conditional on survival to 6 months. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

17 Figure 16 Recipient age and relative risk of mortality at 5 years after transplant, for adult heart transplants performed between January 2001 and June 2004 and surviving to 1 year. The dashed lines show the 95% confidence intervals. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

18 Figure 17 Cumulative incidence of the leading causes of death for adult heart transplants performed between January 1992 and June CAV, coronary allograft vasculopathy; CMV, cytomegalovirus; lymph/PTLD, lymphoma or post-transplant lymphoproliferative disease. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

19 Figure 18 Relative incidence of leading causes of death by time since adult heart transplant, for deaths occurring January 1998—June CAV, coronary allograft vasculopathy; CMV, cytomegalovirus. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

20 Figure 19 Relative risk of cardiac allograft vasculopathy (CAV) development within 8 years of adult heart transplant, according to donor age, donor gender, and recipient gender. Includes transplants performed July 1997 to June 2001, conditional on survival to transplant discharge. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

21 Figure 20 Freedom from severe renal dysfunction, stratified by era, for transplants performed between April 1994 and June Severe renal dysfunction is defined as creatinine > 2.5 mg/dl, dialysis, or renal transplant. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions

22 Figure 21 Functional status of adult heart recipients transplanted in the United States, expressed as the Karnofsky score. Follow-ups submitted from March 2005 to June 2009. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2010 International Society for Heart and Lung Transplantation Terms and Conditions


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