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Management of Myositis-Related Interstitial Lung Disease

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Presentation on theme: "Management of Myositis-Related Interstitial Lung Disease"— Presentation transcript:

1 Management of Myositis-Related Interstitial Lung Disease
Julie Morisset, MD, Cheilonda Johnson, MD, Eric Rich, MD, Harold R. Collard, MD, FCCP, Joyce S. Lee, MD  CHEST  Volume 150, Issue 5, Pages (November 2016) DOI: /j.chest Copyright © 2016 American College of Chest Physicians Terms and Conditions

2 Figure 1 Radiologic appearance of myositis-related interstitial lung disease (ILD). A, Nonspecific interstitial pneumonia (NSIP) pattern. High-resolution CT (HRCT) scan demonstrating the characteristic radiographic appearance of NSIP with peripheral ground glass and irregular reticulation with subpleural sparing. B, Organizing pneumonia (OP). HRCT scan demonstrating the characteristic radiographic appearance of OP with rounded regions of peribronchovascular and subpleural consolidation. C, Combination of NSIP and OP pattern. HRCT scan demonstrating peripheral ground glass and peripheral consolidation. CHEST  , DOI: ( /j.chest ) Copyright © 2016 American College of Chest Physicians Terms and Conditions

3 Figure 2 Histopathologic appearance of myositis-related interstitial lung disease (ILD). A, Fibrosing and cellular nonspecific interstitial pneumonia (NSIP) pattern. Lung biopsy specimen demonstrates uniform thickening of the alveolar septa by fibrosis and chronic inflammation. B, Organizing pneumonia (OP). A lung biopsy specimen demonstrating polypoid rounded plugs of granulation tissue are noted within alveolar spaces. CHEST  , DOI: ( /j.chest ) Copyright © 2016 American College of Chest Physicians Terms and Conditions

4 Figure 3 Proposed algorithm for the treatment of myositis-related interstitial lung disease (ILD). AZA = azathioprine; CsA = cyclosporine A; CYC = cyclophosphamide; HRCT = high-resolution CT; IVIG = IV immunoglobulin; MMF = mycophenolate mofetil; PFTs = pulmonary function tests. CHEST  , DOI: ( /j.chest ) Copyright © 2016 American College of Chest Physicians Terms and Conditions


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