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Comparison of the efficacy and safety of single-agent and doublet chemotherapy in advanced non-small cell lung cancer in the elderly: A meta-analysis Gaetan Des Guetz, Bernard Uzzan, Patrick Nicolas, Dominique Valeyre, Georges Sebbane, Jean-François Morere Critical Reviews in Oncology / Hematology Volume 84, Issue 3, Pages (December 2012) DOI: /j.critrevonc Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 1 Flow-chart of the meta-analysis.
Critical Reviews in Oncology / Hematology , DOI: ( /j.critrevonc ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 2 Forest plot of studies including or not a platinum salt and assessing overall survival. By convention, a Hazard Ratio<1 corresponds to a higher survival for doublet chemotherapy compared with single agent. Critical Reviews in Oncology / Hematology , DOI: ( /j.critrevonc ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 3 Forest plot of studies including or not a platinum salt and assessing response rate. By convention, a Hazard Ratio<1 corresponds to higher response for doublet chemotherapy compared with single agent. Critical Reviews in Oncology / Hematology , DOI: ( /j.critrevonc ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 4 Forest plot of studies including or not a platinum salt and assessing toxicities. By convention, a Hazard Ratio>1 corresponds to a higher frequency of side effect among patients receiving doublet chemotherapy compared with single agent. Critical Reviews in Oncology / Hematology , DOI: ( /j.critrevonc ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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