1. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Polygenic model of psoriasis. Four psoriasis genes (PS1-PS4) are depicted on 4 different chromosomes, contributing to psoriasis (solid symbol) in a simple pedigree. In the model shown, each allele acts in a dominant fashion to produce disease, but only when disease alleles at the other 3 loci are present. Circles indicate female members; squares, male members.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

2. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Increased risk for psoriasis in relatives of psoriatic probands. The risk ratio is defined as the prevalence of psoriasis in the indicated type of relative, divided by the prevalence of psoriasis in the general population (assumed here to be 1.5%). Type I psoriasis has an age of onset of younger than 40 years; type II psoriasis, 40 years or older. Data are from Christophers and Henseler, modified from Elder et al.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

3. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Examples of linkage (A), association (B), and association and linkage disequilibrium in families (C). The chromosome-shaped symbols depict a marker locus on top, and the disease gene below. The marker allele assumes one of several values, and the disease gene can encode a disease allele (PS) or a normal allele (N).
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

4. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Results from our genome-wide scan for psoriasis genes under dominant (A) and recessive (B) genetic models. Linkage results expressed as lod scores are presented as a function of genetic distance along the chromosomes, which are aligned end-to-end with the short arm of each chromosome on the left. The peak corresponding to PSORS1 in the major histocompatibility complex (MHC) is indicated, along with several other linkage peaks that have also been observed in psoriasis and other inflammatory/immune disorders with skin involvement. cM indicates centimorgan. Modified from Nair et al by permission of Oxford University Press.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

5. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Transmission of HLA haplotypes in a familial psoriasis pedigree. Ovals demonstrate transmission of 2 different HLA-Cw6–bearing risk haplotypes from unaffected married-in pedigree members in the second generation. Rectangles demonstrate transmission of a third HLA-Cw6–bearing haplotype from an unaffected individual in the top generation. The transmission events marked with asterisks would be scored as recombinant by typical genetic linkage programs, thereby decreasing evidence of linkage. Circles indicate female members; squares, male members; solid shapes, affected members; slash, deceased; and shaded boxes, a recombination event between HLA-B and HLA-DR. Modified from Nair et al by permission of The University of Chicago Press.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

6. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Map of the major histocompatibility complex (MHC) class I region, showing the location of risk haplotype 1 (RH1) and nearby genes (solid bars) and pseudogenes (striped bars). Pseudogenes contain DNA sequence variations that prevent them from being produced as functional proteins. Distances from HLA-C have been determined from the DNA sequence of the MHC.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

7. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Hypothetical interaction for PSORS1 (psoriasis suseptibility 1) and the non–major histocompatibility complex genes in psoriasis, assuming a multiplicative model of gene-gene interaction consistent with the model of inheritance shown in Figure 1. The allele frequency of PSORS1 has been estimated on the basis of the frequency of HLA-Cw6 in white populations. The disease allele frequencies for genes X, Y, and Z are assumed to be equal. Note that high disease allele frequencies of genes X, Y, and Z are required to produce a final population prevalence of 2%.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.

8. Copyright © 2001 American Medical Association. All rights reserved.
From: The Genetics of Psoriasis 2001The Odyssey Continues
Arch Dermatol. 2001;137(11): doi: /archderm
Figure Legend:
Deleterious effects of high disease allele frequencies on the ability to detect linkage. The examples shown are to be illustrative and not to depict all situations that can be encountered. D and D′ indicate 2 genetically different disease alleles at a particular locus;N, any normal allele at that locus. Circles indicate female members; squares, male members; and solid shapes, affected members.
Date of download: 10/21/2017
Copyright © 2001 American Medical Association. All rights reserved.