1. Volume 9, Issue 8, Pages 743-750 (August 2017)
A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics 
Natalie S. Schmitz, PharmD, Linda E. Krach, MD, Lisa D. Coles, PhD, Usha Mishra, MS, Suresh K. Agarwal, PhD, James C. Cloyd, PharmD, Robert L. Kriel, MD 
PM&R 
Volume 9, Issue 8, Pages (August 2017)
DOI: /j.pmrj
Copyright © 2017 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

2. Figure 1 Subject participation.
PM&R 2017 9, DOI: ( /j.pmrj )
Copyright © 2017 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

3. Figure 2
Mean (± standard deviation) change from baseline sedation scores after 20-mg PO and 15-mg 10-minute and 60-minute infusions (n = 12).
PM&R 2017 9, DOI: ( /j.pmrj )
Copyright © 2017 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

4. Figure 3
Maximum increase in sedation score by route of administration and dose.
PM&R 2017 9, DOI: ( /j.pmrj )
Copyright © 2017 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

5. Figure 4
Mean (± standard deviation) plasma-concentration time profiles after oral (PO) and intravenous (IV) baclofen (n = 12 for each baclofen dose).
PM&R 2017 9, DOI: ( /j.pmrj )
Copyright © 2017 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

6. Figure 5
Effect of route of administration and dose on maximum concentration (Cmax) and AUC(0-inf) (mean ± standard deviation). Cmax = maximum concentration; AUC(0-inf) = Area Under the Curve 0 to infinity.
PM&R 2017 9, DOI: ( /j.pmrj )
Copyright © 2017 American Academy of Physical Medicine and Rehabilitation Terms and Conditions