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Survival After Single Versus Bilateral Lung Transplantation for High-Risk Patients With Pulmonary Fibrosis  Eric S. Weiss, MD, MPH, Jeremiah G. Allen,

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Presentation on theme: "Survival After Single Versus Bilateral Lung Transplantation for High-Risk Patients With Pulmonary Fibrosis  Eric S. Weiss, MD, MPH, Jeremiah G. Allen,"— Presentation transcript:

1 Survival After Single Versus Bilateral Lung Transplantation for High-Risk Patients With Pulmonary Fibrosis  Eric S. Weiss, MD, MPH, Jeremiah G. Allen, MD, Christian A. Merlo, MD, MPH, John V. Conte, MD, Ashish S. Shah, MD  The Annals of Thoracic Surgery  Volume 88, Issue 5, Pages (November 2009) DOI: /j.athoracsur Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Distribution of lung transplantation (LTx) indications from years 1998 to Data presented as percentage of total adult lung transplantation cases with number of cases per year given below on the x-axis. The lung allocation score (LAS) was implemented in May (CF = cystic fibrosis; COPD = chronic obstructive pulmonary disease; IPF = idiopathic pulmonary fibrosis.) Based on Organ Procurement and Transplantation Network data, May 2008. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Study design. (IPF = idiopathic pulmonary fibrosis; LAS = lung allocation score; LTx = lung transplantation; Pulm = pulmonary.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Kaplan-Meier estimates of 1-year survival for high-risk idiopathic pulmonary fibrosis (IPF) patients (dashed line) and low-risk IPF patients (solid line) by lung allocation score (LAS). Based on Organ Procurement and Transplantation Network data, May 2008. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Lowess smooth plot of Martingale residuals over lung allocation score (LAS) range, demonstrating visually the increased risk associated with single lung transplantation (SLT) at higher LAS scores. (BLT = bilateral lung transplantation.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Kaplan-Meier estimates of 1-year survival for (A) high-risk idiopathic pulmonary fibrosis (IPF) patients and (B) low-risk IPF patients undergoing bilateral lung transplantation (BLT [solid line]) versus single lung transplantation (SLT [dashed line]). (LAS = lung allocation score.) Based on Organ Procurement and Transplantation Network data, May 2008. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Cox proportional hazards regression for mortality at 1 year after lung transplantation at various cutoffs of lung allocation score (LAS). Hazard ratio and 95% confidence interval (CI) provided. (BLT = bilateral lung transplantation; SLT = single lung transplantation.) Based on Organ Procurement and Transplantation Network data, May 2008. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions


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