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Volume 91, Issue 1, Pages 57-62 (January 1987)
Pulmonary Fibrosis following Pneumonia Due to Acute Legionnaires’ Disease Jean Chastre, M.D., Ganesh Raghu, M.D., Paul Soler, Ph.D., Patrick Brun, M.D., Françoise Basset, M.D., Claude Gibert, M.D. CHEST Volume 91, Issue 1, Pages (January 1987) DOI: /chest Copyright © 1987 The American College of Chest Physicians Terms and Conditions
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Figure 1 Fibrotic thickening of alveolar structures, with cuboidal metaplasia of remaining alveolar epithelium (case 1) (hematoxylin-eosin, original magnification × 125). CHEST , 57-62DOI: ( /chest ) Copyright © 1987 The American College of Chest Physicians Terms and Conditions
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Figure 2 Alveolar wall revealing cuboidal type 2 pneumocytes, thickened epithelial and capillary basement membranes (asterisks), collagen (col) bundles, and elastic fibers (el), as, Alveolar space; ep, epithelial lining; and ca, capillary (case 1) (uranyl acetate and lead citrate, original magnification × 2,600). CHEST , 57-62DOI: ( /chest ) Copyright © 1987 The American College of Chest Physicians Terms and Conditions
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Figure 3 Alveolar tissue. Epithelial alveolar lining cells are lifted from their basement membrane, which is largely disrupted between two arrowheads, ca, Capillary; f, fibroblast; ep, epithelial cell; as, alveolar space; ic, inflammatory cells; and m, macrophage (case 5) (uranyl acetate and lead citrate, original magnification × 2,300). CHEST , 57-62DOI: ( /chest ) Copyright © 1987 The American College of Chest Physicians Terms and Conditions
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Figure 4 Area with prominent intra-alveolar organization. Areas of intra-alveolar fibrosis (asterisks) are less cellular than remaining alveolar structures (case 4) (hematoxylin-eosin, original magnification × 125). CHEST , 57-62DOI: ( /chest ) Copyright © 1987 The American College of Chest Physicians Terms and Conditions
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Figure 5 A (left), Immunofluorescent micrograph of alveolar walls stained by antibody to collagen type 4. Note disruption of type 4 collagen along basement membrane (lower half) compared to relatively normal areas (upper half) (case 4) (original magnification × 400). B (right), Immunofluorescent micrograph of alveolar walls stained by antibody to collagen type 3, showing positive reaction in interstitium and within alveolar space (case 4). (original magnification × 250). CHEST , 57-62DOI: ( /chest ) Copyright © 1987 The American College of Chest Physicians Terms and Conditions
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