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Wijtske Annema, PhD, Hendrik M

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1 HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels 
Wijtske Annema, PhD, Hendrik M. Willemsen, MD, Jan Freark de Boer, PhD, Arne Dikkers, MSc, Markus van der Giet, MD, Wybe Nieuwland, MD, Anneke C. Muller Kobold, PhD, L. Joost van Pelt, MD, PhD, Riemer H.J.A. Slart, MD, PhD, Iwan C.C. van der Horst, MD, PhD, Robin P.F. Dullaart, MD, PhD, René A. Tio, MD, PhD, Uwe J.F. Tietge, MD  Journal of Clinical Lipidology  Volume 10, Issue 6, Pages (November 2016) DOI: /j.jacl Copyright © 2016 National Lipid Association Terms and Conditions

2 Figure 1 Selected HDL functionalities are impaired in patients with an acute myocardial infarction. Efflux (A), antioxidative (B), and anti-inflammatory functionality (C) of HDL from non-MI patients (n = 33) and patients with acute myocardial infarction (non-STEMI, n = 41 and STEMI, n = 37). Horizontal lines represent means, symbols individual measurements. (D) Changes in the efflux functionality of HDL relative to changes in the anti-inflammatory functionality of HDL. The fitted regression lines were calculated with linear regression analysis. The Pearson correlation coefficient is given. **P < .01, ***P < .001. TBARS, thiobarbituric acid reactive substances; VCAM-1, vascular cell adhesion molecule-1. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

3 Figure 2 Impaired HDL functionality in acute myocardial infarction patients is related to plasma myeloperoxidase levels. Changes in the efflux (A) and anti-inflammatory (B) functionality of HDL from non-MI patients (n = 33) and patients with acute myocardial infarction (non-STEMI, n = 41 and STEMI, n = 37) relative to changes in maximal plasma levels of myeloperoxidase. The fitted regression lines were calculated with linear regression analysis. Pearson correlation coefficients are given. VCAM-1, vascular cell adhesion molecule-1. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

4 Figure 3 HDL functionality is associated with myocardial infarction. Data are expressed as odds ratios and their respective 95% confidence intervals (CIs) for myocardial infarction in the upper risk quartile compared to the three low-risk quartiles combined. Squares represent odds ratios, and error bars indicate 95% confidence intervals. The dashed reference line denotes an odds ratio of 1.0. CRP, C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

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