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Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism  S.M. Uddin, B. Richbourgh,

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Presentation on theme: "Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism  S.M. Uddin, B. Richbourgh,"— Presentation transcript:

1 Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism  S.M. Uddin, B. Richbourgh, Y.-S. Yi, C. Liu  Osteoarthritis and Cartilage  Volume 23, Pages A144-A145 (April 2015) DOI: /j.joca Copyright © Terms and Conditions

2 Fig 1A LIPUS enhances chondrogenesis and neutralizes IL-1beta B) LIPUS restores IL-1beta induced chondrocytes migration inhibition. Osteoarthritis and Cartilage  , A144-A145DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2. A)combine treatment of PGRN and LIPUS show synergistic effects in chondrocytes anabolism. B) LIPUS +PGRN treatment enhances saffron O staining and protect against cytokines induce cartilage degradation. Osteoarthritis and Cartilage  , A144-A145DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Figure 3. PGRN and LIPUS role in inhibition of inflammatory and activation of chondrogenic pathways.
Osteoarthritis and Cartilage  , A144-A145DOI: ( /j.joca ) Copyright © Terms and Conditions


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