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Volume 29, Issue 3, Pages (March 1956)

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Presentation on theme: "Volume 29, Issue 3, Pages (March 1956)"— Presentation transcript:

1 Volume 29, Issue 3, Pages 241-257 (March 1956)
The Treatment of Human Pulmonary Tuberculosis With Cycloserine:* Progress Report**  ISRAEL G. EPSTEIN, M.D., F.C.C.P., K.G.S. NAIR, M.D., LINN J. BOYD, M.D., F.A.C.P.  Diseases of the Chest  Volume 29, Issue 3, Pages (March 1956) DOI: /chest Copyright © 1956 The American College of Chest Physicians Terms and Conditions

2 Figure 1A H. V. Chest x-ray film on admission: caseous pneumonic tuberculous lesion in right upper lobe with cavity. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

3 Figure 1B H. V. Note drop of temperature to normal on third day where it has remained on cycloserine therapy. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

4 Figure 1C H. V. Following a slight initial loss of weight during hemoptysis she has gained weight rapidly and continues to do so. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

5 Figure 1D H. V. X-ray film taken after 12 weeks of cycloserine therapy. Note resolution of inflammatory disease. Cavity can no longer be clearly defined. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

6 Figure 1E H. V. X-ray film after 30 weeks of cycloserine shows complete resolution of the caseous lesions in the right upper lobe; there is a minimal residual productive infiltration. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

7 Figure 2A P. B. Chest x-ray film on admission. Caseous pneumonic tuberculous lesion involving the left mid-lung field with cavity formation. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

8 Figure 2B P. B. Temperature elevated at institution of cycloserine therapy came down to normal during 10 days of treatment, where it has remained. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

9 Figure 2C P. B. Weight increase following onset of cycloserine therapy. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

10 Figure 2D P. B. X-ray film following 24 weeks of cycloserine therapy shows resolution of lesion in left lung with minimal residual productive infiltration. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

11 Figure 3A D. M. Chest x-ray film on admission. Extensive caseous pneumonic tuberculous lesion in lower half of left lung. Left diaphragm paralyzed and elevated because of previous phrenic nerve operation. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

12 Figure 3B D. M. X-ray film at onset of cycloserine therapy shows a marked progression of the disease in the left lung with a large upper lobe cavity. There has also been a spread of the disease into the right upper lobe. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

13 Figure 3C D. M. Temperature that had been elevated for over six months came down to normal within a month and has remained so. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

14 Figure 3D D. M. His weight which was decreasing steadily since admission rose immediately on institution of cycloserine. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

15 Figure 3E D. M. X-ray film taken after 12 weeks of cycloserine therapy. The left lung has become atelectatic with disappearance of the large left upper lobe cavity. There has been some clearing in the right upper lobe. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

16 Figure 4A G. D. Chest x-ray film taken 15 months prior to cycloserine therapy shows bilateral extensive tuberculous disease with a large right apical cavity. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

17 Figure 4B G. D. X-ray film taken at onset of cycloserine therapy. There has been an increase of the size of the cavity in the right upper lobe. The lesion in the lower lobes is stationary. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

18 Figure 4C G. D. His body weight which had been stationary for more than four months began to increase almost immediately after onset of cycloserine. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

19 Figure 4D G. D. X-ray film taken after nine months of cycloserine therapy. There has been a marked decrease of shadows in both lower lobes. The right upper lobe cavity is smaller and its walls are thinned. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

20 Figure 5A J. T. Chest x-ray film taken seven months prior to cycloserine therapy reveals a caseous pneumonic lesion in left mid-lung field with cavitation. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

21 Figure 5B J. T. X-ray film taken at the onset of cycloserine therapy. There has been in increase in the severity of the left lung lesion. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

22 Figure 5C J. T. Body weight was stationary for over a year prior to cycloserine therapy but rapidly rose on institution of therapy. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions

23 Figure 5D J. T. X-ray film taken after seven months of cycloserine therapy. There has been complete resolution of caseous disease and closure of cavities with minimal residual productive infiltration. Diseases of the Chest  , DOI: ( /chest ) Copyright © 1956 The American College of Chest Physicians Terms and Conditions


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