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B A P-AXL P-AXL AXL AXL P-MET P-MET MET MET P-Akt-473 P-Akt-473 AKT

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Presentation on theme: "B A P-AXL P-AXL AXL AXL P-MET P-MET MET MET P-Akt-473 P-Akt-473 AKT"— Presentation transcript:

1 B A P-AXL P-AXL AXL AXL P-MET P-MET MET MET P-Akt-473 P-Akt-473 AKT
GAPDH GAPDH Suni 1 2 5 - S786-O + 0.2 0.5 (μM) Suni 1 4 7 - S786-O + 14 28 (days) Supplementary Figure S O cell develops sunitinib-resistance after two-weeks treatment of sunitinib at the dose of 1μM. (A) 786-O cells were treated with sunitinib at the concentration as indicated for 2 weeks. Then the cells were deprived of sunitinib for 24 hours. S786-O is the cell that were treated with 1μM sunitinib for over 6 months. The cells were lysed and analyzed with western blot with the antibodies as indicated. (B) 786-O cells were treated with sunitinib at 1μM for different time as indicated. Then the cells were deprived of sunitinib for 24 hours. S786-O is the cell that were treated with 1μM sunitinib for over 6 months. The cells were lysed and analyzed with western blot with the antibodies as indicated. The western blot represents 3 different repeats.

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