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Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal.

Published byLeslie Henderson Modified over 6 years ago

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Presentation on theme: "Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal."— Presentation transcript:

1 Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma  Roberto Marasca, Paola Vaccari, Mario Luppi, Patrizia Zucchini, Ilaria Castelli, Patrizia Barozzi, Angela Cuoghi, Giuseppe Torelli  The American Journal of Pathology  Volume 159, Issue 1, Pages (July 2001) DOI: /S (10) Copyright © 2001 American Society for Investigative Pathology Terms and Conditions

2 Figure 1 Lymph node from case 5 with NMZL. (Giemsa; original magnification, ×400). The American Journal of Pathology  , DOI: ( /S (10) ) Copyright © 2001 American Society for Investigative Pathology Terms and Conditions

3 Figure 2 Gel electrophoresis of PCR amplifications of the CDR3s of cases 1, 4, and 5 obtained with primers specific for the FR3 (A) and FR2 (B)IgH regions. A: Amplicons of the same length were clearly present in patients 1 and 4 whereas in case 5 they were present as a smear with a faint band. B: Clonal bands of the same length were present only in cases 4 and 5. M, molecular weight marker ΦX174 Hae III digested; NC, DNA-free negative control. The American Journal of Pathology  , DOI: ( /S (10) ) Copyright © 2001 American Society for Investigative Pathology Terms and Conditions

4 Figure 3 Sequence analysis of the VH1-69 homologous segment in three HCV-positive NMZL cases (cases 1, 4, and 5). VH codons are numerated on the VH1-69 germ-line sequence. Bold letters: replacement mutations. The American Journal of Pathology  , DOI: ( /S (10) ) Copyright © 2001 American Society for Investigative Pathology Terms and Conditions

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