1. Intravascular Hemolysis and Acute Renal Failure After Mitral and Aortic Valve Repair 
Beatrice Concepcion, MD, Stephen M. Korbet, MD, Melvin M. Schwartz, MD 
American Journal of Kidney Diseases 
Volume 52, Issue 5, Pages (November 2008)
DOI: /j.ajkd
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

2. Figure 1
Glomerular architecture is normal, with thin delicate basement membranes, patent capillaries, and normal mesangial matrix and cellularity. Note that the adjacent proximal tubules contain numerous granules of hemosiderin (periodic acid–Schiff stain; original magnification ×164).
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

3. Figure 2
Proximal tubules show widespread evidence of acute tubular necrosis, including thinning of the epithelium, loss of brush border, sloughing of cellular debris into the lumen, and mitotic figures. Note the granules of hemosiderin diffusely present in the tubular cytoplasm (periodic acid–Schiff stain; original magnification ×330).
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

4. Figure 3
Hemosiderin-laden tubular epithelium stained with Prussian blue stain (original magnification ×330).
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

5. Figure 4
Urine cytological examination shows degenerating tubular epithelial cells containing copious granules of hemosiderin (Papanicolaou stain; original magnification ×330).
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions