1. Preventive approach: Iodine micronutrient formulation for pre-birth

3. علی رغم این که یدرسانی در کشور ما در کودکان، نوجوانان و زمان غیر بارداری به اندازه کافی انجام می شود اما نتایج مطالعه ای که در سال 1394 از 12 استان کشور منتشر شده است نشان می دهد که میانگین ید ادرار زنان باردار در سه دوره سه ماهه بارداری در 12 استان مورد بررسی 98 میکروگرم در لیتر بوده است که از حداقل ید مطلوب دوران بارداری که 150 میکروگرم در لیتر می باشد بسیار پایین تر است.

4. Iodine in pregnancy
Adequate intake of this mineral is needed for maternal thyroid hormone production, and thyroid hormone is needed for myelination of the central nervous system and is thus essential for normal fetal brain development.

5. Changes in thyroid function in pregnancy
 TBG
 E
 FT4
 TSH
iodine
TPO Ab
 HCG
 TSH
 FT4
 goiter
 Tg
 TSH
 TSH
ID= Iodine Deficiency
E =estrogen
thyroxinebinding globulin (TBG)
placental type 3 iodothyronine deiodinas
 placental DI III
 T4
Delange: Int.J. Endocrinol. Metab. 2: 1, 2004

6. Iodine deficiency
If iodine deficiency leads to inadequate production of thyroid hormone during pregnancy, irreversible brain damage in the fetus may occur
Severe maternal iodine deficiency has also been associated with increased incidence of miscarriage, stillbirth, and birth defects

7. Importance of iodine in brain development
50,000 brain cells produced/second in the developing fetal brain
100 billion brain cells in adult
One million billion connections between these brain cells: Determine IQ

8. Iodine deficiency is now accepted as the most common cause of preventable brain damage in the world.
Thus, adequate intake of the mineral throughout pregnancy is critical

9. American Thyroid Association's
Recommendation
To achieve a total of 250 μg iodine ingestion daily, in North America all women who are planning pregnancy, pregnant, or breastfeeding, should supplement their diet with a daily oral supplement that contains 150 μg of iodine.
Thyroid 2011; 21:

10. Formulation Challenges
Content uniformity
Stability
Detection (slight amount of iodine in a complex matrix)

11. Content uniformity
The content uniformity test is to ensure that every dosage form contains equal amount of drug substance
150 mcg in each tablet and 150 g iodine in 180 kg matrix

12. Stability
Elemental iodine readily sublimes and is then rapidly lost to the atmosphere through diffusion
Iodine tablets have to pass accelerated (6 months, 40°C/75% RH) and long term (12 months ,25°C/60% RH) stability test.
To need a stable form