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Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489):

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Presentation on theme: "Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489):"— Presentation transcript:

1 Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US ): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trial  Joel Gallant, MD, Prof Adriano Lazzarin, MD, Anthony Mills, MD, Chloe Orkin, MD, Daniel Podzamczer, MD, Pablo Tebas, MD, Prof Pierre-Marie Girard, MD, Indira Brar, MD, Eric S Daar, MD, David Wohl, MD, Prof Jürgen Rockstroh, MD, Xuelian Wei, PhD, Joseph Custodio, PhD, Kirsten White, PhD, Dr Hal Martin, MD, Andrew Cheng, MD, Erin Quirk, MD  The Lancet  DOI: /S (17) Copyright © 2017 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial profile B/F/TAF=bictegravir, emtricitabine, and tenofovir alafenamide. DTG/ABC/3TC=dolutegravir, abacavir, and lamivudine. The Lancet DOI: ( /S (17) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

3 Figure 2 Proportion of participants with HIV-1 RNA less than 50 copies per mL Missing-as-excluded analysis. Error bars represent 95% CIs. B/F/TAF=bictegravir, emtricitabine, and tenofovir alafenamide. DTG/ABC/3TC=dolutegravir, abacavir, and lamivudine. The Lancet DOI: ( /S (17) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

4 Figure 3 Mean percentage change from baseline in hip and lumbar spine bone mineral density As determined by dual energy X-ray absorptiometry scan. Error bars represent 95% CIs. B/F/TAF=bictegravir, emtricitabine, and tenofovir alafenamide. DTG/ABC/3TC=dolutegravir, abacavir, and lamivudine. *B/F/TAF versus DTG/ABC/3TC at week 48 by ANOVA. The Lancet DOI: ( /S (17) ) Copyright © 2017 Elsevier Ltd Terms and Conditions


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