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Part I: Liver function in oncology: biochemistry and beyond
Kathryn M Field, MBBS Hons, Chris Dow, FRCPA, Dr Michael Michael, MBBS Hons The Lancet Oncology Volume 9, Issue 11, Pages (November 2008) DOI: /S (08) Copyright © 2008 Elsevier Ltd Terms and Conditions
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Figure 1 Histology of healthy liver
Portal tract contains bile duct, hepatic artery, and portal vein (upper right); central vein shown (lower left); and hepatocytes line sinusoids in centre of image. Cords and plates of hepatocytes are one-cell thick between sinusoids. Haematoxylin and eosin stain, ×200 magnification. The Lancet Oncology 2008 9, DOI: ( /S (08) ) Copyright © 2008 Elsevier Ltd Terms and Conditions
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Figure 2 Histopathological injury secondary to chemotherapy
Macrovesicular and microvesicular steatosis, ×400 magnification (A, arrows) and sinusoidal dilatation, ×200 magnification (B, arrows) in patients given neoadjuvant FOLFOX (fluorouracil, leucovorin, and oxaliplatin) before liver resection for metastatic colorectal cancer. Cells in both panels stained with haematoxylin and eosin. The Lancet Oncology 2008 9, DOI: ( /S (08) ) Copyright © 2008 Elsevier Ltd Terms and Conditions
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Figure 3 Hepatic veno-occlusive disease after chemotherapy and abdominal radiotherapy (A) Fibrosis and near-obliteration of venule (arrow), with atrophy and congestion of hepatic parenchyma (haematoxylin and eosin stain, ×200 magnification). (B) Collagen of venule wall (arrow) and loose fibrosis has almost obliterated venule lumen (Masson trichrome stain, ×200 magnification). The Lancet Oncology 2008 9, DOI: ( /S (08) ) Copyright © 2008 Elsevier Ltd Terms and Conditions
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Figure 4 Assessment before chemotherapy: identification of patients at risk of hepatotoxicity The Lancet Oncology 2008 9, DOI: ( /S (08) ) Copyright © 2008 Elsevier Ltd Terms and Conditions
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