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The CYP2B6 G516T polymorphism influences CD4+ T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region.

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Presentation on theme: "The CYP2B6 G516T polymorphism influences CD4+ T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region."— Presentation transcript:

1 The CYP2B6 G516T polymorphism influences CD4+ T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon  Maria Alice Freitas Queiroz, Rogério Valois Laurentino, Ednelza da Silva Graça Amoras, Mauro Sérgio Moura de Araújo, Samara Tatielle Monteiro Gomes, Sandra Souza Lima, Antonio Carlos Rosário Vallinoto, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Luiz Fernando Almeida Machado  International Journal of Infectious Diseases  Volume 55, Pages 4-10 (February 2017) DOI: /j.ijid Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Amplification pattern of CYP2B6 G516T (rs ) genotyping by real-time PCR with the TaqMan SNP Genotyping Assay system (Applied Biosystems, Foster City, CA, USA). International Journal of Infectious Diseases  , 4-10DOI: ( /j.ijid ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Biochemical and immunological variables of HIV-1-infected patients according to the CYP2B6 G516T genotypes: (A) creatinine, (B) urea, (C) aspartate aminotransferase (AST), and (D) alanine aminotransferase (ALT) plasma concentrations; (E) CD4+ and (F) CD8+ T-cell counts. *Mann–Whitney test. International Journal of Infectious Diseases  , 4-10DOI: ( /j.ijid ) Copyright © 2016 The Authors Terms and Conditions

4 Figure 3 CD4+ T-cell counts according to the CYP2B6 G516T genotypes among (A) patients receiving treatment with an NNRTI, and (B) patients receiving treatment with a PI. *Mann–Whitney test. International Journal of Infectious Diseases  , 4-10DOI: ( /j.ijid ) Copyright © 2016 The Authors Terms and Conditions


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