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Figure 1 The heterogenous landscape of triple-negative breast cancer

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1 Figure 1 The heterogenous landscape of triple-negative breast cancer
Figure 1 | The heterogenous landscape of triple-negative breast cancer. Different approaches to dissect the complex molecular landscape of TNBCs are presented. a | Histological subtypes. Some rare but relevant subtypes are shown for illustrative purposes. b | Gene-expression-based subtypes of triple-negative breast cancer (TNBC) according to PAM5023. c | Gene-expression-based subtypes defined by Lehmann et al.29. d | Integrative clusters (IntClust) of genomic and transcriptomic data applied to basal-like breast cancer (BLBC) defined by gene-expression5. e | Heterogeneity of tumour-infiltrating lymphocytes. Tumours with low, intermediate and high lymphocyte infiltration are shown for illustrative purposes. BL1, basal-like 1; BL2, basal-like 2; IM, immunomodulatory; LAR, luminal androgen receptor; M, mesenchymal; MSL, mesenchymal stem-like; UNC, unclassified; UNS, unstable. Bianchini, G. et. al. (2016) Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease Nat. Rev. Clin. Oncol. doi: /nrclinonc

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