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Changes in salivary cortisol and corticosteroid receptor-α mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia 

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Presentation on theme: "Changes in salivary cortisol and corticosteroid receptor-α mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia "— Presentation transcript:

1 Changes in salivary cortisol and corticosteroid receptor-α mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia  Marco Bonifazi, Anna Lisa Suman, Caterina Cambiaggi, Andrea Felici, Giovanni Grasso, Leda Lodi, Marzia Mencarelli, Michela Muscettola, Giancarlo Carli  Psychoneuroendocrinology  Volume 31, Issue 9, Pages (October 2006) DOI: /j.psyneuen Copyright © 2006 Elsevier Ltd Terms and Conditions

2 Figure 1 Mean concentrations (±SE) of salivary free cortisol in patients with fibromyalgia at each time of day before and after the 3-week multidisciplinary treatment program. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2006 Elsevier Ltd Terms and Conditions

3 Figure 2 Mean (horizontal line) and individual values of the expression of GR-α mRNA in peripheral blood mononuclear cells of fibromyalgia patients before and after the treatment program. The resulting GR-α mRNA abundance data were normalized against β-actin mRNA abundance. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2006 Elsevier Ltd Terms and Conditions

4 Figure 3 Mean values (±SD) of pressure pain threshold (kg/cm2) of tender point sites at pre-admission and before and after the 3-week multidisciplinary treatment program. ANOVA: trapezius F=4.83, p=0.016; occiput F=19.10, p<0.001; ant cervical F=7.13, p=0.003; supraspinatus F=14.06, p<0.001; second rib F=12.29, p<0.001; lateral epicondyle F=5.10, p=0.013; gluteal F=1.53, p=0.234; greater trochanter F=1.85, p=0.175; knee F=4.76, p=0.016. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2006 Elsevier Ltd Terms and Conditions


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