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Antibodies to Collagen in Patients with Idiopathic Pulmonary Fibrosis

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Presentation on theme: "Antibodies to Collagen in Patients with Idiopathic Pulmonary Fibrosis"— Presentation transcript:

1 Antibodies to Collagen in Patients with Idiopathic Pulmonary Fibrosis
George Nakos, M.D., Alex Adams, R.R.T., Nikos Andriopoulos, M.D.  CHEST  Volume 103, Issue 4, Pages (April 1993) DOI: /chest Copyright © 1993 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibody activity against native collagen type I, II, III and IV (r = –0.84, p<0.001). CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibody activity against collagen chains type α1 + α1(I), α1(II) and α1(III) (r = –0.75, p<0.01). CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibody activity against native or collagen chain type I (r = –0.57, p<0.05). CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibodies activity against native or collagen chain type III (r = –0.8, p<0.001). CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Correlation between number of types of positive anticollagen antibodies in each patient and the median value (–log2) of antibodies activity (r = 0.91, p<0.01). CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

7 Figure 6 Correlation between duration (months) of the disease and factor of activity (factor of activity = median value of anticollagen antibodies titer • number of collagen types with positive anticollagen antibodies [r = –0.87, p<0.001]). CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

8 Figure 7 Titers of anticollagen antibodies in a representative sample of serum from patient with IPF. The sample was chromatographed on a Sephadex G-200 column. CHEST  , DOI: ( /chest ) Copyright © 1993 The American College of Chest Physicians Terms and Conditions


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