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Volume 60, Issue 1, Pages 183-190 (January 2014)
Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure Annika Mutanen, Päivi Heikkilä, Jouko Lohi, Taneli Raivio, Hannu Jalanko, Mikko P. Pakarinen Journal of Hepatology Volume 60, Issue 1, Pages (January 2014) DOI: /j.jhep Copyright © 2013 European Association for the Study of the Liver Terms and Conditions
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Fig. 1 Serum FGF21 concentrations in patients with (n=16) and without (n=14) steatosis and controls (n=59). Median (95% confidence interval) serum levels of FGF21 are displayed. ∗Patients with steatosis had higher serum FGF21 level compared to patients without steatosis (p=0.002). FGF21 levels were comparable in patients without steatosis and controls (p=0.865). Journal of Hepatology , DOI: ( /j.jhep ) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions
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Fig. 2 Serum FGF21 concentration in patients with liver steatosis (grade 0; n=14, grade 1; n=9, grade 2; n=4, grade 3; n=3). Data are presented as median (95% CI). ∗Grade 3 vs. grade 0 [median 8473pg/ml (range 624–20,345) vs. 108pg/ml (32–568); p<0.001], grade 3 vs. grade 1 [8473pg/ml (624–20,345) vs. 627pg/ml (21–2614), p⩽0.001], grade 3 vs. grade 2 [8473pg/ml (624–20,345) vs. 270pg/ml (154–1372), p=0.001]. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions
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Fig. 3 Correlation of serum FGF21 levels (Log transformation) with liver steatosis grade [r=0.589, p=0.001 (A)], duration of parenteral nutrition (PN) [r=0.580, p<0.001, (B)], and percentage of age-adjusted small bowel length [r=−0.368, p=0.029, (C)]. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions
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