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Volume 76, Issue 4, Pages (April 2011)

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Presentation on theme: "Volume 76, Issue 4, Pages (April 2011)"— Presentation transcript:

1 Volume 76, Issue 4, Pages 507-511 (April 2011)
A hypothetical relationship between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation – bioinformatic and algorithmic approach  Sanjiban Sekhar Roy, C.H. Hsu, Z.H. Wen, C.S. Lin, Chiranjib Chakraborty  Medical Hypotheses  Volume 76, Issue 4, Pages (April 2011) DOI: /j.mehy Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Fig. 1 Alignment scores of protein sequences of nuclear reprogramming factors for iPS development. (A) Alignment score between sequences (notation Seq (x:y) meaning alignment score between sequence x, and sequence y). (B) Scatter distribution of scores. (C) Scores connected by smoothed line without marker. Medical Hypotheses  , DOI: ( /j.mehy ) Copyright © 2010 Elsevier Ltd Terms and Conditions

3 Fig. 2 Phylogenetic tree construction using Phylogeny.fr software. (A) Phylogram of four factors which are having sequence alignments score ⩾10. (B) Cladogram of four factors which are having sequence alignments score ⩾10. Medical Hypotheses  , DOI: ( /j.mehy ) Copyright © 2010 Elsevier Ltd Terms and Conditions

4 Fig. 3 Phylogenetic tree for algorithm analysis. (A) Cladogram of four factors for tree algorithm analysis. (B) Representation binary tree equivalent to Cladogram. Medical Hypotheses  , DOI: ( /j.mehy ) Copyright © 2010 Elsevier Ltd Terms and Conditions

5 Fig. 4 Scheme showing the hypothetical relationship between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation. Medical Hypotheses  , DOI: ( /j.mehy ) Copyright © 2010 Elsevier Ltd Terms and Conditions


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