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Fig. 1 The effects of modelling global volume for the analysis of PDD relative to controls. Atrophy in PDD shown (A) compensated for differences in head.

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Presentation on theme: "Fig. 1 The effects of modelling global volume for the analysis of PDD relative to controls. Atrophy in PDD shown (A) compensated for differences in head."— Presentation transcript:

1 Fig. 1 The effects of modelling global volume for the analysis of PDD relative to controls. Atrophy in PDD shown (A) compensated for differences in head size, with significant changes in the temporal, occipital and frontal lobes and subcortical regions at P < 0.001 uncorrected, and (B) as regional changes in grey matter, above that occurring globally, with significant changes in the thalamus, caudate and occipital lobe at P < 0.01 uncorrected. From: Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls Brain. 2004;127(4): doi: /brain/awh088 Brain | The Guarantors of Brain 2004

2 Fig. 2 Atrophy in Parkinson’s disease patients shown (A) compensated for differences in head size, with significant grey matter loss observed in the right frontal lobe at P < 0.001 uncorrected, and (B) as regional changes in grey matter, above that occurring globally, with less significant changes in the right frontal lobe at P < 0.01 uncorrected. From: Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls Brain. 2004;127(4): doi: /brain/awh088 Brain | The Guarantors of Brain 2004

3 Fig. 3 Grey matter volume loss in PDD relative to Parkinson’s disease, accounting for differences in head size (P < 0.001 uncorrected). Atrophy was observed in the occipital lobe bilaterally, although less significant on the right. From: Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls Brain. 2004;127(4): doi: /brain/awh088 Brain | The Guarantors of Brain 2004

4 Fig. 4 Atrophy in Alzheimer’s disease patients shown (A) compensated for differences in head size and (B) as regional changes in grey matter, above that occurring globally presented at P <  There is significant grey matter volume reduction bilaterally in the hippocampus, parahippocampal gyrus and inferior temporal lobe. From: Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls Brain. 2004;127(4): doi: /brain/awh088 Brain | The Guarantors of Brain 2004


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