1. EGFR mutation in Austrian patients with NSCLC: a retrospective study
Hochmair MJ1, Miler M1, Setinek U1, Kirchbacher K2, Mohn-Staudner A1, Kaufmann M1, Kapfhammer I1, Arns MB3, Patocka K4, Burghuber OC1
1 Department of Respiratory and Critical Care Medicine, Otto Wagner Hospital, Vienna, Austria
2 2.Medizinische Abteilung – Lungenabteilung, Wilhelminenspital, Lehrkrankenhaus der medizinischen Universität Wien, Austria
3Pulmologische Abteilung , LKH Hochegg, Grimmenstein, Austria
4Abteilung für Atmungs- und Lungenerkrankungen, KH Hietzing, Vienna, Austria
Correspondence:
Introduction
Mutations of the Epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) predicts the response to tyrosine kinase inhibitors. Commonly mutations occur more in never smokers, adenocarcinomas, women and East Asians. In the largest European screening trial the frequency of caucasian Spanish patients was 16.6% (1). However, the frequency of EGFR mutations in NSCLC from Austrian patients is unknown.
Results
EGFR mutations were found in 65 out of 406 patients (16,01%).
52 patients (12.81%) carried an activated Mutation (Exon 19 Deletion and Exon 21 L858R).
Figure 1. Distribution of different EGFR Mutationtypes
Aim
To evaluate the prevalence of EGFR mutation in Austrian patients with NSCLC.
Methods
From January 2010 to May 2011 tumor tissue from bronchoscopy, CT-guided and ultrasound guided biopsies and surgical specimen with histological type of Adenocarcinomas and NSCLC NOS (Not Otherwise Specified) excluding squamous cell carcinomas and large cell carcinomas were tested for EGFR mutations from 3 hospitals in Vienna and 1 hospital in Lower Austria. The mutation detection was performed with the TheraScreen EGFR29MutationKit from DxS on a Light Cycler 480.
Conclusion
These results indicate that Austrian patients with NSCLC harbor somatic EGFR mutations at a frequency similar to other European caucasian patients with NSCLC.
Reference: [1] IScreening for epidermal growth factor receptor muations in lung cancer. Rosell et al. NEJM 361 (10) 2009 1