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NAT testing in Poland E. Brojer, M. Łętowska, A. Gronowska Institute of Hematology and Blood Transfusion, Warsaw, Poland Population: 38.5 mln Reg. Blood.

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Presentation on theme: "NAT testing in Poland E. Brojer, M. Łętowska, A. Gronowska Institute of Hematology and Blood Transfusion, Warsaw, Poland Population: 38.5 mln Reg. Blood."— Presentation transcript:

1 NAT testing in Poland E. Brojer, M. Łętowska, A. Gronowska Institute of Hematology and Blood Transfusion, Warsaw, Poland Population: 38.5 mln Reg. Blood Transf. Centers: 21 Donations: 1mln/year Introduction of NAT HCV in plasma for fractionation March 2000 HCV in all donations - Jan 2002

2 Reference Lab (IHBT, Warsaw ) certification for all NAT Laboratories Cobas AmpliScreen Roche plasma pools, 48 donations 8 Labs in RBT Centers TMA HIV/HCV Chiron single donations 2 Labs in RBT Centers NAT Test format HCVcoreAg used supplementarily, (mainly in emergency) BALTIC SEA LITHUANIA RUSSIA BELARUS UKRAINE SLOVAKIA CZECH REP. Słupsk Olsztyn Zielona Góra Wałbrzych Wrocław Łódź Kraków Radom Kielce Katowice Opole Szczecin Lublin Gdańsk Bydgoszcz Białystok Poznań Kalisz Racibórz Rzeszów Warszawa GERMANY

3 Frequency of HCV positive window period donations Plasma pool testing: 34/ 1.80 mln HCVcore Ag: 10/ 0.34 mln Single donation HIV/HCV : 0/ 0.39 mln Overall frequency 44/ 2.5 mln Elevated ALT in 30% of HCV RNA positive donors

4 31 Follow up and look back studies of HCV RNA positive/anti- HCV negative donors RNAHCV(+) /anti-HCV (-) anti-HCV detected in all donors, observed for more than 3 months HCV RNA was not detected in 2/35 (6 and 20 months after eroconversion) 3 11 months 0 8

5 HCV genotype frequency in HCV RNA(+)/antiHCV(-) blood donors (%)

6 3.2x x10 7 Viral load in HCV RNA positive/anti-HCV negative blood donors


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