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Volume 68, Pages S24-S28 (July 2005)

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Presentation on theme: "Volume 68, Pages S24-S28 (July 2005)"— Presentation transcript:

1 Volume 68, Pages S24-S28 (July 2005)
Cinacalcet HCl: A novel treatment for secondary hyperparathyroidism in stage 5 chronic kidney disease  L. Darryl Quarles  Kidney International  Volume 68, Pages S24-S28 (July 2005) DOI: /S (15) Copyright © 2005 International Society of Nephrology Terms and Conditions

2 Figure 1 Molecular targets regulating parathyroid gland function include, in rank order of importance, CASR, VDR, and a hypothetical phosphate sensing mechanism. Kidney International  , S24-S28DOI: ( /S (15) ) Copyright © 2005 International Society of Nephrology Terms and Conditions

3 Figure 2 Changes in serum PTH, calcium, phosphorus, and Ca × P product in placebo- and cinacalcet HCl (AMG073)-treated patients enrolled in a phase II trial. Reprinted with permission from Lippincott Williams & Wilkins. Kidney International  , S24-S28DOI: ( /S (15) ) Copyright © 2005 International Society of Nephrology Terms and Conditions

4 Figure 3 Mean (±SEM) plasma parathyroid hormone levels as a function of time in the combined phase III trials comparing placebo with cinacalcet HCl treatment in stage 5 CKD patients. Reprinted with permission from Massachusetts Medical Society. Modified from National Kidney Foundation K/DOQI™, Am J Kidney Dis 43:S1–S201, 2004. Kidney International  , S24-S28DOI: ( /S (15) ) Copyright © 2005 International Society of Nephrology Terms and Conditions


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