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Long-term economic value of hypofractionated prostate radiation: Secondary analysis of a randomized trial  K. Ranh Voong, MD MPH, Lincy S. Lal, PhD, Deborah.

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Presentation on theme: "Long-term economic value of hypofractionated prostate radiation: Secondary analysis of a randomized trial  K. Ranh Voong, MD MPH, Lincy S. Lal, PhD, Deborah."— Presentation transcript:

1 Long-term economic value of hypofractionated prostate radiation: Secondary analysis of a randomized trial  K. Ranh Voong, MD MPH, Lincy S. Lal, PhD, Deborah A. Kuban, MD, Thomas J. Pugh, MD, J. Michael Swint, PhD, Joy Godby, Seungtaek Choi, MD, Andrew K. Lee, MD MPH, Pamela J. Schlembach, MD, Steven J. Frank, MD, Sean E. McGuire, MD PhD, Karen E. Hoffman, MD MPH  Advances in Radiation Oncology  Volume 2, Issue 3, Pages (July 2017) DOI: /j.adro Copyright © 2017 American Society for Radiation Oncology Terms and Conditions

2 Figure 1 Decision tree comparing conventional intensity modulated radiation therapy (CIMRT) to dose-escalated moderately hypofractionated intensity modulated radiation therapy (HIMRT). Probabilities of maximum late bowel and urinary toxicities were obtained using patient-level data from a randomized trial with a median follow-up of 6 years. Advances in Radiation Oncology 2017 2, DOI: ( /j.adro ) Copyright © 2017 American Society for Radiation Oncology Terms and Conditions

3 Figure 2 Tornado analysis ranking in order of influence the univariate effects of probabilities (p_) and cost (c_) variations on expected value (mean cost). c_, cost of parameter; p_, probability of parameter; CIMRT, conventional intensity modulated radiation therapy; HIMRT, dose-escalated hypofractionated intensity modulated radiation therapy; 0-1, maximum grade 0 or grade 1 toxicity; 2-3, maximum grade 2 or grade 3 toxicity; EV, expected value in 2014 U.S. dollars. Advances in Radiation Oncology 2017 2, DOI: ( /j.adro ) Copyright © 2017 American Society for Radiation Oncology Terms and Conditions

4 Figure 3 Components of total cost for patients with organ-confined prostate cancer treated with dose-escalated moderately hypofractionated intensity modulated radiation therapy (HIMRT) or conventional intensity modulated radiation therapy (CIMRT). No men who were treated with CIMRT developed both grade 2-3 bowel and grade 2-3 urinary toxicities. Thus, cost components in 2014 U.S. dollars for this subgroup are not displayed. The number of patients in each subgroup is displayed at the far end of the bar graph. Advances in Radiation Oncology 2017 2, DOI: ( /j.adro ) Copyright © 2017 American Society for Radiation Oncology Terms and Conditions

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