1. Page 1 What is TNFWhat is TNF? --Creative BioMart

2. Page 2 What is Tumor necrosis factor (TNF) superfamily? Tumor necrosis factorsTumor necrosis factors (TNF) superfamily composes of a group of cytokines and their receptors which can reduce cell death (apoptosis). This superfamily is composed of 19 ligands and 29 receptors in humans. TNFα and Lymphotoxin-alpha (LTα) is first identified members of the family.

3. Page 3 TNF has also been called cachectin and differentiating factor (DIF) due to its role in chronic wasting disease and its ability to promote differentiation in some hematopoetic cells. Since its discovery, more than 20 homologues of TNF have been identified with 15-20% identity between family members, all of which have affects upon the immune system. Thus, there is a TNF superfamily composed of related proteins.

4. Page 4 TNF promotes the apoptosis, programmed cell death, or necrosis of certain cancer cell lines in pM concentrations. Apoptosis and necrosis is induced by TNF activation of pro-death pathways.

5. Page 5 TNF is involved or implicated in many immunological disorders, as well as various disease states. TNF is a mediator of inflammation observed in patients with rheumatoid arthritis and inhibition of TNF with neutralizing antibodies can stop progression of the disease. TNF is involved in the inflammation observed during the onset of multiple sclerosis and type 1 diabetes.

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