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Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med.

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Presentation on theme: "Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med."— Presentation transcript:

1 Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med. 2013;159(8): 532-542. doi:10.7326/0003-4819-159-8-201310150-00006 Summary of evidence search and selection. * One article provided outcomes for both diabetic and venous ulcers. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2 Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med. 2013;159(8): 532-542. doi:10.7326/0003-4819-159-8-201310150-00006 Healed diabetic ulcers. Each dot represents 1 trial. Shaded rows indicate therapies for which meta-analyses were possible (see Figure 2 and Appendix Figure 2). BSE = biological skin equivalent; HBOT = hyperbaric oxygen therapy; NPWT = negative pressure wound therapy; PDGF = platelet-derived growth factor; PRP = platelet-rich plasma. * Shire Regenerative Medicine, San Diego, California. † Organogenesis, Canton, Massachusetts. ‡ Compared biological dressing with BSE (Dermagraft) and found no significant difference (15). § Compared biological dressing with PDGF and found no significant difference (14). ∥ A second study of silver cream did not report the proportion of healed ulcers (36). ¶ Found extracorporeal shock wave therapy to be more effective than HBOT (40). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3 Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med. 2013;159(8): 532-542. doi:10.7326/0003-4819-159-8-201310150-00006 Meta-analyses of the proportion of diabetic ulcers healed. BSE = biological skin equivalent; M–H = Mantel–Haenszel; PDGF = platelet-derived growth factor. * Shire Regenerative Medicine, San Diego, California. † Organogenesis, Canton, Massachusetts. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4 Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med. 2013;159(8): 532-542. doi:10.7326/0003-4819-159-8-201310150-00006 Healed venous ulcers. Each dot represents 1 trial. Shaded rows indicate therapies for which meta-analyses were possible (see Appendix Figure 3). BSE = biological skin equivalent; EMT = electromagnetic therapy; HBOT = hyperbaric oxygen therapy; IPC = intermittent pneumatic compression; PRP = platelet-rich plasma. * Shire Regenerative Medicine, San Diego, California. † Organogenesis, Canton, Massachusetts. ‡ Found silver cream to be more effective than tripeptide copper cream (57). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5 Date of download: 9/19/2016 From: Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers: A Systematic Review Ann Intern Med. 2013;159(8): 532-542. doi:10.7326/0003-4819-159-8-201310150-00006 Meta-analyses of the proportion of venous ulcers healed. M–H = Mantel–Haenszel. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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