1. 11/21/2014 CFAR Mentoring Core Facilities at UCSF and Beyond Teri Liegler, PhD Director ARI-UCSF Laboratory of Clinical Virology CFAR Virology Core Laboratory tliegler@sfgh.ucsf.edu

2. 11/21/2014 CFAR Mentoring What is a core facility? NIH Definition –“A centralized, shared resource that provides scientific investigators with access to instruments; technologies; services; cellular, animal or human study support; and expert consultation” >80 at UCSF and affiliated institutions

3. Core Facility Mission at UCSF Service: Provides cutting-edge and state-of-the-art technologies and expertise in an efficient operation Education: Provides explicit training in the proper application of technology and analysis of the data produced R & D: Provides an environment for technology and application development, broadening the use and applicability of research tools globally and enhancing local discovery 11/21/2014 CFAR Mentoring

4. 11/21/2014 CFAR Mentoring Why and when to use a core? Expand your research scope and capacity Save time using services already up and running Save money by ‘renting’ rather than ‘buying’ Consult with experts throughout the study –Especially at the inception stage –Most cores offer consultation at no cost

5. 11/21/2014 CFAR Mentoring What are the CFAR cores? Clinical/Population Science –Jeff Martin, Steve Deeks Immunology –Elizabeth Sinclair, Jeff Milush Pharmacology –Fran Aweeka Specimen Banking –John Greenspan, Yvonne DeSouza Virology –Teri Liegler

6. 11/21/2014 CFAR Mentoring Why are CFAR cores special? Cores are a business, but not really… –Mandate to support & enhance institutional research –Restricted on how we can make and spend money –Must be cost neutral, can’t show profit CFAR funds 5 cores to promote ‘Value Added’ services –Education, training and mentoring –State of the art equipment –New assay development –“Conception − to − Publication” support for projects

7. Services Provided by Virology Core Molecular Diagnostic Assays PCR Sequencing HIV Viral Load VL fluid and cell associated Genotypic drug resistance Specimen Services Processing Shipping Standardized and Customized services

8. 11/21/2014 CFAR Mentoring Core synergy for effective and efficient use Specimens Nucleic Acid Extraction and Modification HIV Sequencing Genomic SNP Analysis Bioinformatics

9. 11/21/2014 CFAR Mentoring Core Synergy at Work! CFAR Clin and Specimen Core CFAR Immunology Core CFAR Virology Core UCSF Genomics Core Manuscript =

10. 11/21/2014 CFAR Mentoring How do I find the right Core?

11. 121410 CFAR Mentoring

12. 11/21/2014 CFAR Mentoring How do I find the right Core?

13. 11/21/2014 CFAR Mentoring But can I afford using a core? You get what you pay for! –Quality, accountability and experience Sometimes, time is $$ May partially cover costs for new development work Consult with core director on study design, hypothesis, sample selection and services early in process Institutional supplements

14. 11/21/2014 CFAR Mentoring $500 - $5,000 CTSI-SOS application cycle (spring & fall) Apps on RAP website: http://rap.ucsf.edu/core exploratoryhttp://rap.ucsf.edu/core

15. Pilot program up to $4,000 Remove barriers for 1 st time core users Expand the scope and breadth of core users Spark new offerings and collaborations with cores Easy app, rapid turnaround, 6 month duration

16. 11/21/2014 CFAR Mentoring Thank You! Questions? tliegler@sfgh.ucsf.edu 206-8929