1. Science & Technology Centers Program Center for Science of Information Bryn Mawr Howard MIT Princeton Purdue Stanford Texas A&M UC Berkeley UC San Diego UIUC University of Hawaii 1 National Science Foundation/Science & Technology Centers Program

2. Science & Technology Centers Program 1.Science of Information 2.Management  Objectives  External Advisory Committee  Sustainability Plan  Brief History of CSoI 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 2

3. Science & Technology Centers Program 3  SCIENCE OF INFORMATION builds on Shannon’s principles to address key challenges in understanding information that nowadays is not only communicated but also acquired, curated, organized, aggregated, managed, processed, suitably abstracted and represented, analyzed, inferred, valued, secured, and used in various scientific, engineering, and socio-economic processes. CSoI MISSION: Advance science and technology through a new quantitative understanding of the representation, communication and processing of information in biological, physical, social and engineering systems.  Claude Shannon laid the foundation of information theory, demonstrating that problems of data transmission and compression (i.e., reliably reproducing data) can be precisely modeled formulated, and analyzed.

4. Science & Technology Centers Program 4  Extend Information Theory to meet new challenges in biology, economics, data & social sciences, and physical distributed systems.  Understand new aspects of information (embedded) in structure, time, space, semantics, dynamic information, limited resources, complexity, representation invariant information, and cooperation & dependency.

5. Science & Technology Centers Program 1.Science of Information 2.Management  Objectives  External Advisory Committee  Sustainability Plan  Brief History 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 5

6. Science & Technology Centers Program Research: To provide mechanisms for synergistic research and development of foundational principles, methods, and applications of science of information. Education: To educate and train the next generation of practitioners. Diversity: To deeply engage students, researchers, and affiliated personnel from underrepresented groups in all aspects of the project. Knowledge Transfer: To facilitate seamless transfer of knowledge to the broader academic and commercial world.

7. Science & Technology Centers Program 7 Management Chart

8. Science & Technology Centers Program Projects within the Center are managed by the Center Director, Manager, and Executive Committee via management, solicitation, and assessment: –Track progress of each project –Terminate projects no longer relevant or demonstrating insufficient progress through new mechanism of competitive funding –Evaluate the success of collaborative investigations. Metrics (letter from ExC, annual evaluation) –Publication of quality peer-reviewed papers –Development of software, industry outreach, intellectual property, etc –Collaborations between investigators, e.g., joint publications and grants –Development of educational material that illustrate fundamental developments in the domain –Assessment of progress reports within the Center

9. Science & Technology Centers Program Composition: –Advisory to the Center’s Director –Center leadership (Director and Manager ex officio) –Chair of the Executive Committee: P. R. Kumar –Members: Anantharam, Goldsmith, Grama, D. Kumar, Shor, Subramaniam, Verdu. Coordination: –Regular meetings conducted through telephone and/or video conference –Senior personnel from projects attend by invitation as needed. –Manage new and ongoing projects; deal with issues that have arisen, and discuss possible future directions (fiscal and intellectual) –Action items from meeting are distributed promptly –Distribution of funds with an eye on impact and fairness

10. Science & Technology Centers Program High Level Goal: To enhance the long-term impact and research agenda of the Center. Composition: The External Advisory Committee (EAC), will consist of representatives from other institutions of higher education, government, and industry. Sustainability: With guaranteed support from Purdue University, the Center is well-positioned to thrive well beyond the next five-year funding period. However, an important goal of the Center leadership is to find ways to bring sustained funding from goverment agencies, private foundations, and industry to build on the Center's agenda. Attention: One member of EAB should be present during the site visit

11. Science & Technology Centers Program Specific objectives for the EAC: - Help identify new funding mechanisms for Center-related research to complement existing funding and maintain aspects of the program after NSF funding ends. - Help identify Center-related research ripe for tech transfer, and facilitate such transfer - Forge and/or strengthen connections between industry and the Center - Help establish connections between the Center and other research organizations with overlapping interests.

12. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  CSoI Team  Sustainability Plan  Brief History 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 12

13. Science & Technology Centers Program Bryn Mawr College: D. Kumar Howard University: R. Rwebangira MIT: P. Shor (co-PI) Purdue University (lead): W. Szpankowski (PI) Princeton University: S. Verdu (co-PI) Stanford University: A. Goldsmith (co-PI) Texas A&M: P.R. Kumar University of California, Berkeley: Bin Yu (co-PI) University of California, San Diego: S. Subramaniam UIUC: O. Milenkovic University of Hawaii: P. Santhanam Bin Yu, U.C. Berkeley Sergio Verdú, Princeton Peter Shor, MIT Andrea Goldsmith, Stanford 13 R. Aguilar, M. Atallah, S. Datta, A. Grama, J. Neville, D. Ramkrishna, L. Si, V. Rego, M. Ward, D. Xu, C. Liu, L. Burge, N. Lynch, R. Rivest, M. Sudan,Y. Polyanskiy, W. Bialek, S. Kulkarni, C. Sims, T. Cover, A. Ozgur, T. Weissman, V. Anantharam, J. Gallant, T. Courtade, M. Mahoney, D. Tse, T. Coleman, Y. Baryshnikov, M. Raginsky. Wojciech Szpankowski, Purdue

14. Science & Technology Centers Program  Nobel Prize (Economics): Sims  National Academies: NAS – Bialek, Rivest, Shor, Sims, Verdu, Yu NAE – Datta, Lynch, Kumar, Ramkrishan, Rice, Rivest, Verdu  Turing Award – Rivest  Shannon Award – Verdu, Tse (Cover)  Nevanlinna Prize – Sudan and Shor  Richard W. Hamming Medal – Cover and Verdu  Humboldt Research Award, A. Bement Jr. Award – Szpankowski  Swartz Prize in Neuroscience – Bialek  IEEE Field Award for Control Systems – Kumar  Edwin Howard Armstrong Achievement Award – Goldsmith 14

15. Science & Technology Centers Program Director – Wojciech Szpankowski Managing Director – Bob Brown Education Director – Brent Ladd Diversity Director – Kelly Andronicos Multimedia Specialist – Mike Atwell Administrative Asst. – Kiya Smith Kiya Smith Administrative Asst. Mike Atwell Multimedia Specialist Brent Ladd Education Director Bob Brown Managing Director Kelly Andronicos Diversity Director 15

16. Science & Technology Centers Program 16 RESEARCH THRUSTS: 1. Information & Communication 2. Knowledge Extraction (Data Science) 3. Life Sciences S. Subramaniam T. Weissman J. Neville RESEARCH MISSION: Create a shared intellectual space, integral to the Center’s activities, providing a collaborative research environment that crosses disciplinary and institutional boundaries. A. Grama P. Santhanam David Tse

17. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  CSoI Team  Sustainability Plan  Brief History 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 17

18. Science & Technology Centers Program  Purdue Center for Science of Information  Visitors Program in Science of Information  Proposals to Funding Agencies: - Federal: NSF, MURI, NIH, ARO, … - Private Foundations: Simons, Templeton, Kavli, … - Industry: Bell Labs, Qualcomm, Google, …  International Partnerships (LINCS, ETH, HIIT)  Learning from Existing Centers (IMA, IPAM, DIMACS) 18

19. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  CSoI Team  Sustainability Plan  Brief History 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 19

20. Science & Technology Centers Program Polyanskiy&Wu information non- conservation law Milenkovic/Weissman work biological database compression Grama/Subramaniam temporal/structural motifs in biology Kumar's security Weissman's rate distortion with delay Rivest's zero-knowledge proofs Covers' coordination capacity Verdu's finte blocklength Szpankowski's structural information Tse’s work on DNA assembly Courtade/Weissman multiterminal source coding 20 Organizational workshop May 2010 2010 2006 2008-2009 Feb 9, 2010 Dear Wojciech, It is my pleasure to inform you that we are recommending an award for your STC proposal. Congratulations! I am snowed in and technically, the office is "closed" today, but I thought you would want to get the word. Joan M. Frye, PhD Senior Staff Associate NSF 2012 Grand Challenges CSoI Fellows Channels Program 2013 IT&CSoI summer school Center Fellow (Wang) Bell Lab meeting SoI Day, Berkeley MIT CalTech CMU Berkeley 2014 International Partnerships (LINCS, ETH, HIIT) Symposium on SoI Challenges, Irvine 2007-2008 Sudan's semantics Goldsmith's sampling Bialek's information flow in biology 2011 Sims Nobel Prize, First Summer School Kick-off Workshop

21. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  Organizational Chart  Sustainability Plan 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 21

22. Science & Technology Centers Program 22 Information Knowledge Data Framing the Foundation Practice inspires Theory Theory guides Practice

23. Science & Technology Centers Program 1.Information: Core Principle Structural Information Temporal Information Value of Information 2.Communication & Control: Fundamental Limit Flow of Information in Dynamic/Cooperative Networks Provable Security 3.Data: Framing the Foundations Information-Theoretic Models Precise Complexity (Small Data) Structural Insights into Data 4.Modeling and Analysis: Life Sciences Sequence Analysis Network Inferences, Modeling, and Analysis Information Flow in Human Brain From Energetics to Sequence and Conformations 23

24. Science & Technology Centers Program 24 Figure 3 renewal proposal

25. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  Organizational Chart  Sustainability Plan 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Accomplishments 4. Education and Diversity 5.Knowledge Transfer 6.Budget 25

26. Science & Technology Centers Program  Legacy of new collaboration between different disciplines: Example: Metabolic Phenomena (Ramkrishna, Subramaniam, Raginsky, students) Aging Process (Grama, Subramaniam, students)  Legacy of new collaboration within the same discipline Examples: Genomic Compression (Milenkovic, Weissman, Lynch, Wang), Multiterminal Source Coding (Courtade, Verdu, Weissman)  Legacy of educating new crops of researchers ( Courtade,Grover,Kostina,Oshman,Polyanskiy,..) Example: Conservation of Information? (Polyanskiy and Wu)  Legacy of new research directions - information theory in life sciences (e.g., Tse, Goldsmith, Coleman, Subramaniam, Bialek) - information theory in data modeling (e.g., Courtade, Wiessman)  Legacy of formulating new foundations: - security (Kumar) - structure (e.g., Szpankowski, Grama, Subramaniam, Courtade, Neville) - temporal information (e.g., Verdu, Kostina, Polyanskiy) - value of information (e.g., Sims, Raginsky, Szpankowski) 26

27. Science & Technology Centers Program 1.Cover’s coordination capacity 2.Verdu’s finite delay blocklength capacity 3.Sudan’s semantic analysis and goal-oriented communication 4.Goldsmith’s capacity of sampled Gaussian channel 5.Szpankowski’s structural information 6.Tse’s information theory of DNA assembly 7.Courtade/Weismann multiterminal source coding 8.Kumar’s foundation of security 9.Rivest’s zero knowledge proofs 10.Polyanskiy’s information non-conversation law 11.Grama’s aging process and temporal motifs in biology 12.Coleman’s modeling of neuronal spiking response 27

28. Science & Technology Centers Program  CSoI Fellow: T. Courtade (Verdu & Weissman); now faculty at UC, Berkeley  CSoI Fellow: R. Ma (Coleman & Anantharam & Gallant); now Sr. Scientist at Dexcom  CSoI Fellow: Z. Wang (Weissman, Milenkovic & Lynch) : now UC Irvine  CSoi Fellows: S. Kamath (Verdu & Szpankowski), A. Javanmard (Courtade & Tse)  CSoI Fellows: A. Padakandla (Kumar, Santhanam); A. Magner (Baryshnikov, Grama), Y. Shkel (Raginsky, Verdu), I. Shomorony (Courtade, Tse)  Ramkrishna, Subramaniam & Raginsky: (Purdue, Berkeley, UIUC, and UCSD team)  Neville, Yu, Kulkarni, Courtade (Purdue-Berkeley): machine learning & social networks  Polyanskiy, Kostina, & Verdu (MIT-Caltech--Princeton): temporal capacity  Grama, Subramaniam, Szpankowski (Purdue-UCSD): biological networks  Kumar & Lynch (Texas –MIT): distributed systems and temporal information  D. Kumar, Ward, Ladd, Nelson (Bryn Mawr –Purdue): faculty development (NSF TUES)  D. Kumar, Ward, Ladd, Grover, Ma (CMU,Texas, MIT, OHSU, UCSD): SoI modules  D. Kumar, Rwebangria, Ward, Ladd, Grover (BMC, Purdue, Howard, CMU,..): SoI course  Szpankowski & Baryshnikov (Purdue-UIUC): structural information  Kulkarni, Szpankowski & Imielinski (Princeton-Purdue-Rutgers): big data  Anantharam, Szpankowski &Santhanam (Berkeley, Purdue, Hawaii): models for big data  Tse, Sudan, Weissman (Berkeley, MIT, Stanford): semantics and communication 28

29. Science & Technology Centers Program Interdisciplinary Student Project Teams Selected from Center for Science Information : 1.“Understanding Information-Energy Interactions” Post-doc PI & Advisor: Pulkit Grover (Carnegie Mellon), Student PI: Karthik Ganesan (EECS, UC Berkeley, advsior: Jan Rabaey), Student PI: George Alexandrov (EE, Stanford, advsior: Andrea Goldsmith). 2.“A Fresh Look at Boolean Functions” Post-doc PI/advsior: Thomas Courtade (EE, Stanford/Princeton University), Post-doc PI/advisor: Pulkit Grover (EE, Stanford University & Carnegie Mellon University), Student PI: Madars Virza (EE & CS, MIT, advisor: R. Rivest). 3.“Investigation of Metabolic Phenomena Using Information Theory” Student PI: Frank DeVilbiss (ChemEng, Purdue University, advisor: D. Ramkrishna), Student PI: Pablo Robles-Granda (CS, Purdue University, advisor: Jennifer Neville), Student PI: Mohan Gopaladesikan (STAT, Purdue University, advisor: Mark Daniel Ward), Faculty Advisor: D. Ramkrishna, Chem Eng Purdue University, Faculty Advisor: Maxim Raginsky, ECE, UIUC. 4.“Graph Inference Based on Random Walks” Post-doc PI/advisor: Thomas Courtade (EE, Stanford/Princeton University), Student PI: Victoria Kostina (EE, Princeton University, advisor: Sergio Verdu), Student PI: Suvidha Kancharla (CS, Purdue University, advisor: Jennifer Neville), Faculty advisor: Jennifer Neville (CS & STAT, Purdue University). 5.“Analysis of Information Content of Biological Imaging” Madhivanan (Purdue, advisor: Aguilar), Venkatasubramani (Texas A & M, advisor Dutta), Veikur, Postdoc (John Hopkins, advisor: Shields), Zhang (Purdue, advisor: Ward) 6.“Improving Cancer Therapeutics through Medical Data Analysis’’ Chowdhurry (Stanford, advisor: Goldsmith), DeVilbiss (Purdue, advisor: Ramkrishna), Francisco-Sanchez (Purdue, advisor: Ward) 7.“Quantitative Analysis of Cargo Trafficking and Compartmental Integrity in Lowe Syndrome’’ Ramadesikan (Purdue, advisor: Aguilar), Center Postdoc, Shomorony (Berkeley, advisors: Courtade, Tse) 8.“Development of an Automatic Qunatification Algorithm for Determining Fluorescence Distribution in Yeast Cells’’ Wen-Chieh Hsieh (Purdue, advisor: Aguilar), Leqi Liu (Bryn Mawr, advisor Jia Tao & D. Kumar) 29

30. Science & Technology Centers Program 30 Research Workshops Kickoff Workshop – Chicago, IL – October 6-7, 2010 (28 STC participants and students) 1. Allerton Workshop, IL – September 28, 2010 2. Stanford Workshop – Palo Alto, CA – January 24, 2011 (Princeton – Stanford –Berkeley) 3. UC San Diego Workshop – February 11, 2011 (Berkeley – UCSD) 4. Princeton Workshop – May 2011 (Princeton – Purdue) 5. Purdue Workshop – September 9, 2011 (Berkeley – UCSD – Purdue) 6. Allerton Workshop – September 27, 2011 (Purdue –UIUC) 7. UCSD Workshop on Neuroscience, February 2012 (UCSD – Berkeley) 8. Princeton Grand & Petit Challenges Workshop, March 2012 (Center-wide) 9. Maui Workshop (ICC), (Industrial Round-Table), May 2012 (Center-wide) 10. MIT Workshop, July 2012 (Center-wide) 11. Students workshop, July 2012 (Center-wide for students) 12. All hands meeting for students, December 2012. 14. Big Data Workshop, March 2013. 15. Bell Lab & CSoI Workshop, Princeton, September 2013. 16. Industrial Workshop, Chicago, September 2013. 17. CSoI Day at Berkeley, November 2013, Purdue, October 2013. 18. All Hands Meeting, Purdue, December 2013. 19. Science of Information Evening, San Diego, ITA, February 2014. 20. CSoI Day at MIT, UIUC, Texas A&M, Howard, April, 2014. 21. Graduate Student workshop, Purdue, Biology and Information, July 2014. 22. Summer School, San Diego, August 2014. 23. Challenges & Opportunities SoI: A Symposium, NAE, Irvine, August 2014. 24. SoI Day in Princeton, September 2015, 25. SoI Day and Industrial Day, Stanford, February 18-19, 2016

31. Science & Technology Centers Program 31 Collaborative Graph 2015

32. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  Organizational Chart  Sustainability Plan 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Value Added 4. Education and Diversity 5.Knowledge Transfer 6.Budget 32

33. Science & Technology Centers Program 1.Summer Schools ( Purdue, 2011&2013, Stanford, 2012, UCSD, 2014 &2015) 2.Center Wide Fellows ( Courtade, Ma, Wang, Kamath, Javanmard, Padakandla, Shkel, Magner, Shomorony) 3.CSoI graduated 45 students (postdocs, grad and undergrad) 4.Information Frontiers Curriculum & Learning HUB ( 18 new courses ) (data information knowledge) 5Intro to Science Information ( BMC, Howard, Purdue, GWU, online) 6Student Teams & Workshops 2012-2016 7NSF TUES Grant and Teaching Workshop 2012-2014 8Channels Scholars Program (Undergrad Mentoring) 9Supplement REU and Professional Development 10. Retention Efforts at the Graduate Level 11. Recruitment of Underrepresented &US Citizens as Postdocs 12. Feature Articles on Diversity in STEM 33 K. Andronicos Integrate cutting-edge, multidisciplinary research and education efforts across the center to advance the training and diversity of the work force B. Ladd D. Kumar M. Ward

34. Science & Technology Centers Program 34

35. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  Organizational Chart  Sustainability Plan 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Accomplishments 4.Education and Diversity 5.Knowledge Transfer 6.Budget 35

36. Science & Technology Centers Program  CSoI members brought $1M funding from industry  CSoI & Bell Labs Workshop, September 2013  Industrial Workshop, Chicago, 2013  International collaborations (LINCS, ETH, Helsinki HIIT)  SoiHub.org refined with wiki to enhance communication  Brown Bag and research seminars, Prestige Lecture Series  Special issue in Proceedings of IEEE on SoI.  Special Session on SoI – CISS’ 12 Princeton, ITA 2014  SoI Day (Berkeley, Texas A&M, UIUC, MIT, Howard, 2014)  Challenges & Opportunities SoI: A Symposium, NAE, Irvine, 2014  Article about CSoI activities in IT News Ananth Grama Develop effective mechanism for interactions between the center and external stakeholder to support the exchange of knowledge, data, and application of new technology.

37. Science & Technology Centers Program 37

38. Science & Technology Centers Program 1.Science of Information 2.Management  Overall Goal  Organizational Chart  Sustainability Plan 3.Research Plan  Main Theme for the Next 5 Years  Overview of Research Plan  Legacy & Accomplishments 4.Education and Diversity 5.Knowledge Transfer 6.Budget 38

39. Science & Technology Centers Program $5M/year :  Student Support (123+64)Post Docs (24)  Faculty Support (30+)Visitors & Collaborators  Education DirectorDiversity Director  Managing Director Administrative Assistance  TravelWorkshops  Advisory Committee Visitors, Speakers, etc  Summer School Competitive Fund

40. Science & Technology Centers Program