1. Cancer biopsies assessment in 2 min using full-field optical coherence tomography Emilie Benoit RRIIDV 31 mai 2016

2. 2 Most patients wait anxiously several days for the results of their biopsies and surgery Pathology reports take 5 days up to 2 weeks Call-backs for repeat surgery or biopsy happen up to 30% of the time No doctor wants to do it! No patient wants to hear it! No payer wants to pay for it! Repeat procedures add costs to payers, provider and patients Pain points in cancer care

3. Decision for further excision or biopsy Surgery / biopsy procedure Solution: accurate and fast optical analysis of tissue 3 1.Place sample in a cassette 2.Automated scan 3.1 µm resolved image 4.Cancer/no cancer decision 2 minutes Tissue analysis ACCURATEFASTACCESSIBLE EASY & EFFICIENT SAVES MONEY

4. Presence of cancer / suspicious areas / specific tissue features Prostate Liver Kidney Lung Para Thyroid… Radiology suite Evaluation of content Qualification for tissue banking Triage in the lab to focus on diagnostic samples Pathology lab Evaluation of margins Skin Mohs Breast … Surgery Real-time decision making tool for multiple uses 4

5. 200 µm Small aggregated glands 93 % accuracy (113 samples, trained pathologist and urologist) Courtesy of Hôpital Cochin, Paris 5 Prostate biopsies – Tumorous glands

6. Fat cells 1 cm LLTech - few minutes Histology - Days Cancerous area LLTech - few minutes Sensitivity 92% and Specificity 77% on cancer (78 samples, 2 pathologists) Sensitivity 88% and Specificity 86% on DCIS (94 samples, 1 trained pathologist) O. Assayag, TCRT Exp, 13(5): 455-468 (2014) Breast margin analysis – LLTech performance 6

7. Faster and optimised Mohs procedure Margins left intact for final histology No technical expertise required 7 Mohs margin analysis

8. Ovarian tissue – fertility preservation Normal ovarian structuresOvarian metastases Courtesy of Leiden University Medical Center 8 FFOCT Histology FFOCT + vitality tests successful

9. 9 19 studies on 12 anatomical sites Breast Eye Prostate & bladder Gastro Pancreas ENT Lung Brain Uterus World-wide clinical research settings

10. 10 Medical imaging industrial companies Health specialists Clinical studies Research projects on new developments -Dynamic FFOCT -FFOCT endoscopy -FFOCT ophthalmology Collaboration opportunities

11. 11 LLTech Emilie Benoit, R&D project manager ebenoit@lltech.fr 01 82 72 61 28 www.lltechimaging.com Thank you ! Contact